The site of the bite: Leishmania interaction with macrophages, neutrophils and the extracellular matrix in the dermis

被引:59
作者
de Menezes, Juliana Perrone [1 ]
Saraiva, Elvira M. [2 ]
da Rocha-Azevedo, Bruno [3 ,4 ]
机构
[1] Oswaldo Cruz Fdn FIOCRUZ, Goncalo Muniz Res Ctr, Salvador, BA, Brazil
[2] Univ Fed Rio de Janeiro, Inst Microbiol Paulo de Goes, Dept Imunol, Rio De Janeiro, Brazil
[3] Univ Fed Rio de Janeiro, Inst Biofis Carlos Chagas Filho, Programa Terapia Celular & Bioengn, Rio De Janeiro, Brazil
[4] Univ Texas SW Med Ctr Dallas, Dept Biophys, 5323 Harry Hines Blvd, Dallas, TX 75390 USA
关键词
Leishmania; Extracellular matrix; Macrophages; Neutrophils; LAMININ-BINDING PROTEIN; CHEMOKINE RECEPTOR EXPRESSION; LUTZOMYIA-LONGIPALPIS; DENDRITIC CELLS; CUTANEOUS LEISHMANIASIS; DONOVANI PROMASTIGOTES; IN-VITRO; AMAZONENSIS PROMASTIGOTES; INTRACELLULAR SURVIVAL; MEDIATED PHAGOCYTOSIS;
D O I
10.1186/s13071-016-1540-3
中图分类号
R38 [医学寄生虫学]; Q [生物科学];
学科分类号
07 ; 0710 ; 09 ; 100103 ;
摘要
Leishmania spp., the causative agents of leishmaniasis, are intracellular parasites, transmitted to humans via the bite of their sand fly vectors. Once inoculated, the promastigotes are exposed to the dermis, which is composed of extracellular matrix (ECM), growth factors and its resident cells. Promastigote forms are phagocytosed by macrophages recruited to the site of the sand fly bite, either directly or after interaction with neutrophils. Since Leishmania is an intracellular parasite, its interaction with the host ECM has been neglected as well as the immediate steps after the sand fly bite. However, promastigotes must overcome the obstacles presented by the dermis ECM in order to establish the infection. Thus, the study of the interaction between Leishmania promastigotes and ECM components as well as the earliest stages of infection are important steps to understand the establishment of the disease, and could contribute in the future to new drug developments towards leishmaniasis.
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