Efficacy and tolerability of amorolfine 5% nail lacquer in combination with systemic antifungal agents for onychomycosis: A meta-analysis and systematic review

被引：14
作者：
Feng, Xiaowei [1 ]
Xiong, Xincai [1 ]
Ran, Yuping [2 ]
机构：
[1] North Sichuan Med Coll, Affiliated Hosp, Dept Dermatovenerol, 63 Wen Hua Rd, Nanchong 637000, Sichuan Provinc, Peoples R China
[2] Sichuan Univ, West China Hosp, Dept Dermatovenerol, Chengdu 610041, Sichuan Provinc, Peoples R China
来源：
DERMATOLOGIC THERAPY | 2017年 / 30卷 / 03期
关键词：
amorolfine; combination; onychomycosis; meta-analysis; RCT; (randomized; controlled trial); SEVERE TOENAIL ONYCHOMYCOSIS; ORAL TERBINAFINE; RANDOMIZED-TRIAL; THERAPY; ITRACONAZOLE; MANAGEMENT; DERMATOMYCOSES; ASSOCIATION; MULTICENTER; INFECTIONS;
D O I：
10.1111/dth.12457
中图分类号：
R75 [皮肤病学与性病学];
学科分类号：
100206 ;
摘要：
The efficacy and safety of amorolfine 5% nail lacquer in combination with systemic antifungal agents in the treatment of the onychomycosis were evaluated. According to our meta-analysis, combination treatment of amorolfine 5% nail lacquer and systemic antifungals can result in higher percentage of complete clearance of onychomycosis. It showed that the experimental combination group was more effective than monotherapy of the systemic antifungals [OR (odds ratio) = 1.97, 95% CI (95% confidence interval) = 1.44-2.69], and no more adverse events happened with the addition of amorolfine 5% nail lacquer (OR = .96, 95% CI = .56-1.63, p = .95). This effect strengthens the fact that amorolfine 5% nail lacquer in combination with systemic antifungal agents was better than the monotherapy of systemic antifungals like itraconazole and terbinafine.
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页数：6
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