Reviving the RNAWorld: An Insight into the Appearance of RNA Methyltransferases

被引：27

作者：

Rana, Ajay K. ^{[1
]}

Ankri, Serge ^{[2
]}

机构：

[1] Govt Jharkhand, Minist Home Affairs, State Forens Sci Lab, Div Biol, Ranchi, Bihar, India

[2] Technion Israel Inst Technol, Ruth & Bruce Rappaport Fac Med, Dept Mol Microbiol, Haifa, Israel

来源：

FRONTIERS IN GENETICS | 2016年 / 7卷

关键词：

RNA world; RNA methylation; DNA methylation; RNA-DNAtransition; evolution; HORIZONTAL GENE-TRANSFER; RIBOSOMAL-RNA; PREBIOTIC SYNTHESIS; PEPTIDE-SYNTHESIS; DNA METHYLTRANSFERASE; CATALYTIC-ACTIVITY; POLYMERASE RIBOZYME; HUMAN DNMT2; METHYLATION; EVOLUTION;

D O I：

10.3389/fgene.2016.00099

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

RNA, the earliest genetic and catalytic molecule, has a relatively delicate and labile chemical structure, when compared to DNA. It is prone to be damaged by alkali, heat, nucleases or stress conditions. One mechanism to protect RNA or DNA from damage is through site-specific methylation. Here, we propose that RNA methylation began prior to DNA methylation in the early forms of life evolving on Earth. In this article, the biochemical properties of some RNA methyltransferases (MTases), such as 2-O-MTases (Rlml/RlmN), spOUT MTases and the NSun2 MTases are dissected for the insight they provide on the transition from an RNA world to our present RNA/DNA/protein world.

引用

页数：9

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