Vanadium Complex Derived from N′-(3-Bromo-5-chloro-2-hydroxybenzylidene)-3-methylbenzohydrazide: Synthesis, Crystal Structure and Biological Activity

被引：0
|
作者：
Han, Zhen-Quan [1 ]
Han, Shuang [2 ]
Wang, Yuan [3 ]
机构：
[1] Qiqihar Univ, Appl Tech Coll, Qiqihar 161006, Peoples R China
[2] Qiqihar Univ, Coll Chem & Chem Engn, Qiqihar 161006, Peoples R China
[3] Qiqihar Environm Monitoring Cent Stn, Qiqihar 161005, Peoples R China
来源：
ACTA CHIMICA SLOVENICA | 2016年 / 63卷 / 01期
关键词：
Hydrazone ligand; Vanadium complex; Crystal structure; Insulin-like activity; COORDINATED OXOVANADIUM(V) COMPLEX; INSULIN-LIKE ACTIVITY; UREASE INHIBITION; DERIVATIVES; AROYLHYDRAZONE; REDUCTION; COMPOUND; LIGANDS; RATS;
D O I：
暂无
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Reaction of VO(acac)(2) with N'-(3-bromo-5-chloro-2-hydroxybenzylidene)-3-methylbenzohydrazide (H2L) in methanol afforded a new mononuclear vanadium(V) complex, [VOL(OMe)(MeOH)]. Structure of the complex has been characterized by physico-chemical methods and single-crystal X-ray diffraction. The complex crystallizes as the monoclinic space group P2(1)/c, with unit cell dimensions a = 13.1345(10) angstrom, b = 18.6279(14) angstrom, c = 7.8983(8) angstrom, beta = 90.248(2)degrees, V = 1932.4(3) angstrom(3), Z = 4, R-1 = 0.0963, wR(2) = 0.2213, S = 1.113. X-ray analysis indicated that the V atom in the complex is in octahedral coordination. The insulin-like activity of the complex was studied, which can stimulate glucose uptake with 2-DOG uptake value of 0.81 nmol / 3 min.
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页码：200 / 203
页数：4
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