Pharmacokinetics of isoniazid in moderately malnourished children with tuberculosis

被引：0
作者：
Roy, V. [1 ]
Gupta, D. [2 ]
Gupta, P. [3 ]
Sethi, G. R. [4 ]
Mishra, T. K. [5 ]
机构：
[1] Maulana Azad Med Coll, Dept Pharmacol, New Delhi, India
[2] Inst Clin Res India, New Delhi, India
[3] All India Inst Med Sci, Dept Pharmacol, New Delhi, India
[4] Maulana Azad Med Coll, Dept Pediat, New Delhi 110002, India
[5] Maulana Azad Med Coll, Dept Biochem, New Delhi 110002, India
来源：
INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE | 2010年 / 14卷 / 03期
关键词：
isoniazid; pharmacokinetics; malnutrition; children; tuberculosis;
D O I：
暂无
中图分类号：
R51 [传染病];
学科分类号：
100401 ;
摘要：
Severe malnutrition is known to affect the pharmacokinetics of isoniazid (INH) in children. However, the effect of moderate malnutrition, which may be more prevalent, Is not known. INH was administered to 20 children with tuberculosis at a single dose of 5 mg/kg, and serial blood samples were collected. The serum INH concentrations were higher in the undernourished group but the pharmacokinetic parameters were comparable with those in the normal nutrition group. Weight gain was significantly more In the undernourished group after 1 month of treatment. The study suggests that INH pharmacokinetics may not be significantly altered in children with moderate malnutrition.
引用
收藏
页码：374 / 376
页数：3
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