Triterpenoids from stems of Kadsura heteroclita

被引：14

作者：

Cao, Liang ^{[1
,2
]}

Li, Bin ^{[1
]}

Shehla, Nuzhat ^{[1
,3
]}

Gong, Li-min ^{[1
]}

Jian, Yu-Qing ^{[1
]}

Peng, Cai-Yun ^{[1
]}

Sheng, Wen-Bing ^{[1
]}

Liu, Le-Ping ^{[1
]}

Cai, Xiong ^{[1
]}

Man, Rong-Yong ^{[4
]}

Liao, Duan-Fang ^{[1
]}

Zhu, Xiao-Qi ^{[2
]}

Choudhary, M. Iqbal ^{[3
]}

Rahman, Atta-ur ^{[3
]}

Wang, Wei ^{[1
]}

机构：

[1] Hunan Univ Chinese Med, Sch Pharm, Innovat Mat Med Res Inst, TCM & Ethnomed Innovat & Dev Int Lab,Acad Attaur, Changsha 410208, Peoples R China

[2] Hunan Acad Agr Sci, Inst Agr Environm & Agroecol, Changsha 410125, Peoples R China

[3] Univ Karachi, Int Ctr Chem & Biol Sci, HEJ Res Inst Chem, Karachi 75270, Pakistan

[4] First Peoples Hosp Huaihua, Clin Expt Res Ctr, Huihua 418000, Peoples R China

来源：

FITOTERAPIA | 2020年 / 140卷

基金：

中国国家自然科学基金;

关键词：

Kadsura heteroclita; Schisandraceae; Xuetong; Tujia ethnomedicine; Triterpenoids;

D O I：

10.1016/j.fitote.2019.104441

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

In the present work, we reported the triterpenoids isolated from n-butanol fraction of Kadsura heteroclita which is a Tujia ethnomedicine with trivial name "Xuetong". This effort resulted in the isolation of six unpresented triterpenoids xuetongsu A-F (1-6), along with five known triterpenoids (7-11). The structures of the reported compounds were established on the 1D, and 2D NMR and HRESIMS spectra, along with CD spectroscopic analysis. Moreover, the absolute stereochemistry of compound 7 was determined by X-ray diffraction analysis. Antioxidant and cytotoxic activities were evaluated for all isolated compounds, compound 7 shown weak cytotoxic activity against HL-60 with IC50 value of 50.0 mu M.

引用

页数：7

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