Triterpenoids from stems of Kadsura heteroclita

被引：14

作者：

Cao, Liang ^{[1
,2
]}

Li, Bin ^{[1
]}

Shehla, Nuzhat ^{[1
,3
]}

Gong, Li-min ^{[1
]}

Jian, Yu-Qing ^{[1
]}

Peng, Cai-Yun ^{[1
]}

Sheng, Wen-Bing ^{[1
]}

Liu, Le-Ping ^{[1
]}

Cai, Xiong ^{[1
]}

Man, Rong-Yong ^{[4
]}

Liao, Duan-Fang ^{[1
]}

Zhu, Xiao-Qi ^{[2
]}

Choudhary, M. Iqbal ^{[3
]}

Rahman, Atta-ur ^{[3
]}

Wang, Wei ^{[1
]}

机构：

[1] Hunan Univ Chinese Med, Sch Pharm, Innovat Mat Med Res Inst, TCM & Ethnomed Innovat & Dev Int Lab,Acad Attaur, Changsha 410208, Peoples R China

[2] Hunan Acad Agr Sci, Inst Agr Environm & Agroecol, Changsha 410125, Peoples R China

[3] Univ Karachi, Int Ctr Chem & Biol Sci, HEJ Res Inst Chem, Karachi 75270, Pakistan

[4] First Peoples Hosp Huaihua, Clin Expt Res Ctr, Huihua 418000, Peoples R China

来源：

FITOTERAPIA | 2020年 / 140卷

基金：

中国国家自然科学基金;

关键词：

Kadsura heteroclita; Schisandraceae; Xuetong; Tujia ethnomedicine; Triterpenoids;

D O I：

10.1016/j.fitote.2019.104441

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

In the present work, we reported the triterpenoids isolated from n-butanol fraction of Kadsura heteroclita which is a Tujia ethnomedicine with trivial name "Xuetong". This effort resulted in the isolation of six unpresented triterpenoids xuetongsu A-F (1-6), along with five known triterpenoids (7-11). The structures of the reported compounds were established on the 1D, and 2D NMR and HRESIMS spectra, along with CD spectroscopic analysis. Moreover, the absolute stereochemistry of compound 7 was determined by X-ray diffraction analysis. Antioxidant and cytotoxic activities were evaluated for all isolated compounds, compound 7 shown weak cytotoxic activity against HL-60 with IC50 value of 50.0 mu M.

引用

页数：7

共 19 条

[1] New Cadinane Sesquiterpenes from the Stems of Kadsura heteroclita [J].

Cao, Liang ;

Shehla, Nuzhat ;

Tasneem, Shumaila ;

Cao, Mengru ;

Sheng, Wenbing ;

Jian, Yuqing ;

Li, Bin ;

Peng, Caiyun ;

Choudhary, M. Iqbal ;

Atta-ur-Rahman ;

Liao, Duan-fang ;

Wang, Wei .

MOLECULES, 2019, 24 (09)

[2] A TRITERPENOID FROM KATSURA-HETEROCLITA [J].

CHEN, YP ;

LIN, ZW ;

ZHANG, HJ ;

SUN, HD .

PHYTOCHEMISTRY, 1990, 29 (10) :3358-3359

[3] Two new triterpene lactones from the stems of Kadsura polysperma [J].

Jia, Zhengwei ;

Lu, Yan ;

Liao, Zhixin ;

Chen, Daofeng .

HELVETICA CHIMICA ACTA, 2007, 90 (06) :1236-1243

[4] Kadcoccinic Acids A-J, Triterpene Acids from Kadsura coccinea [J].

Liang, Cheng-Qin ;

Shi, Yi-Ming ;

Wang, Wei-Guang ;

Hu, Zheng-Xi ;

Li, Yan ;

Zheng, Yong-Tang ;

Li, Xiao-Nian ;

Du, Xue ;

Pu, Jian-Xin ;

Xiao, Wei-Lie ;

Zhang, Hong-Bin ;

Sun, Han-Dong .

JOURNAL OF NATURAL PRODUCTS, 2015, 78 (08) :2067-2073

[5] Genus Kadsura, a good source with considerable characteristic chemical constituents and potential bioactivities [J].

Liu, Jiushi ;

Qi, Yaodong ;

Lai, Hongwu ;

Zhang, Jin ;

Jia, Xiaoguang ;

Liu, Haitao ;

Zhang, Bengang ;

Xiao, Peigen .

PHYTOMEDICINE, 2014, 21 (8-9) :1092-1097

[6] SCHISANLACTONE-A, A NEW TYPE OF TRITERPENOID FROM A SCHISANDRA SP [J].

LIU, JS ;

HUANG, MF ;

ARNOLD, GF ;

ARNOLD, E ;

CLARDY, J ;

AYER, WA .

TETRAHEDRON LETTERS, 1983, 24 (23) :2351-2354

[7] Lignans from Tujia Ethnomedicine Heilaohu: Chemical Characterization and Evaluation of Their Cytotoxicity and Antioxidant Activities [J].

Liu, Yongbei ;

Yang, Yupei ;

Tasneem, Shumaila ;

Hussain, Nusrat ;

Daniyal, Muhammad ;

Yuan, Hanwen ;

Xie, Qingling ;

Liu, Bin ;

Sun, Jing ;

Jian, Yuqing ;

Li, Bin ;

Chen, Shenghuang ;

Wang, Wei .

MOLECULES, 2018, 23 (09)

[8] Cytotoxic 20,24-epoxywithanolides from Physalis angulata [J].

Maldonado, Emma ;

Hurtado, Norma E. ;

Perez-Castorena, Ana L. ;

Martinez, Mahinda .

STEROIDS, 2015, 104 :72-78

[9] DETECTION OF ACTIVATED LYMPHOCYTE SUBSETS BY FLUORESCENCE AND MTT STAINING [J].

SCHAUER, U ;

KROLIKOWSKI, I ;

RIEGER, CHL .

JOURNAL OF IMMUNOLOGICAL METHODS, 1989, 116 (02) :221-227

[10] Kadsuphilactones A and B, two new triterpene dilactones from Kadsura philippinensis [J].

Shen, YC ;

Lin, YC ;

Chiang, MY ;

Yeh, SF ;

Cheng, YB ;

Liao, CC .

ORGANIC LETTERS, 2005, 7 (15) :3307-3310

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