Cancer cell membrane-coated mesoporous silica loaded with superparamagnetic ferroferric oxide and Paclitaxel for the combination of Chemo/Magnetocaloric therapy on MDA-MB-231 cells

被引：65
作者：
Cai, Defu [1 ]
Liu, Likun [1 ]
Han, Cuiyan [2 ]
Ma, Xiaoxing [2 ]
Qian, Jiayi [2 ]
Zhou, Jianwen [1 ]
Zhu, Wenquan [2 ]
机构：
[1] Qiqihar Med Univ, Inst Med & Drug Res, Qiqihar 161006, Peoples R China
[2] Qiqihar Med Univ, Coll Pharm, Qiqihar 161006, Peoples R China
来源：
SCIENTIFIC REPORTS | 2019年 / 9卷 / 1期
关键词：
CONTROLLED DRUG-RELEASE; MAGNETIC HYPERTHERMIA; BREAST-CANCER; STEM-CELLS; NANOPARTICLES; DELIVERY; PARTICLES; LIGANDS; DISEASE; DESIGN;
D O I：
10.1038/s41598-019-51029-8
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
To effectively inhibit the growth of breast cancer cells (MDA-MB-231 cells) by the combination method of chemotherapy and magnetic hyperthermia, we fabricated a biomimetic drug delivery (CSiFePNs) system composed of mesoporous silica nanoparticles (MSNs) containing superparamagnetic ferroferric oxide and Paclitaxel (PTX) coated with MDA-MB-231 cell membranes (CMs). In the in vitro cytotoxicity tests, the MDA-MB-231 cells incubated with CSiFePNs obtained IC50 value of 0.8 mu g L-1, 3.5-fold higher than that of SiFePNs. The combination method of chemotherapy and magnetic hyperthermia can effectively inhibit the growth of MDA-MB-231 cells.
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页数：10
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