Anti-Inflammatory Function of Nodosin via Inhibition of IL-2

被引：17

作者：

Li, Jiyu ^{[1
]}

Du, Junming ^{[1
]}

Sun, Lijuan ^{[2
]}

Liu, Jianwen ^{[2
]}

Quan, Zhiwei ^{[1
]}

机构：

[1] Shanghai Jiao Tong Univ, Inst Dept Gen Surg, Xinhua Hosp, Sch Med, Shanghai 200092, Peoples R China

[2] E China Univ Sci & Technol, Sch Pharm, Shanghai Key Lab Chem Biol, Shanghai 200237, Peoples R China

来源：

AMERICAN JOURNAL OF CHINESE MEDICINE | 2010年 / 38卷 / 01期

关键词：

Nodosin; Anti-Inflammatory; IL-2; Mouse Tumescence Model; ENT-KAURENE DITERPENOIDS; TH1/TH2; CYTOKINES; LYMPHOCYTES; EXPRESSION; DRUGS; CELLS; INFLAMMATION; ACTIVATION; APOPTOSIS; MEDICINE;

D O I：

10.1142/S0192415X10007713

中图分类号：

R [医药、卫生];

学科分类号：

10 ;

摘要：

In order to explore the anti-inflammatory effects of Nodosin from Isodon serra, a traditional Chinese herb medicine, mouse T lymphocytes were incubated with Nodosin. In the current study, Nodosin suppressed the overproduction of the T lymphocytes; moreover, cell mitosis cycle was modulated by interfering with DNA replication in G1 stages via inhibition of IL-2 cytokine secretion at the mRNA level by Nodosin. Interestingly, Xylene-induced mouse tumescence model results suggested Nodosin depressed the murine ear-swelling extent and the level of IL-2 in the blood serum. Finally, Nodosin possessed significant anti-inflammatory effects and is a potential candidate for further clinical trial.

引用

页码：127 / 142

页数：16

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