Dosage compensation: an intertwined world of RNA and chromatin remodelling

被引：53
作者：
Akhtar, A [1 ]
机构：
[1] European Mol Biol Lab, Heidelberg, Germany
来源：
CURRENT OPINION IN GENETICS & DEVELOPMENT | 2003年 / 13卷 / 02期
关键词：
D O I：
10.1016/S0959-437X(03)00016-9
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Dosage compensation mechanisms in flies and mammals provide an exquisite example of chromatin associated RNAs in chromosome-wide transcription regulation. Recent progress shows that chromatin modifications are also closely linked to these processes. Concerted action of the RNA/chromatin-modifying enzymes may play a crucial role in determining transcriptional output. Furthermore, non-coding RNAs appear to play a dual role, being targeting modules as well as encoding for target sites for complex recognition.
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页码：161 / 169
页数：9
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