Dosage compensation: an intertwined world of RNA and chromatin remodelling

被引：53
作者：
Akhtar, A [1 ]
机构：
[1] European Mol Biol Lab, Heidelberg, Germany
来源：
CURRENT OPINION IN GENETICS & DEVELOPMENT | 2003年 / 13卷 / 02期
关键词：
D O I：
10.1016/S0959-437X(03)00016-9
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Dosage compensation mechanisms in flies and mammals provide an exquisite example of chromatin associated RNAs in chromosome-wide transcription regulation. Recent progress shows that chromatin modifications are also closely linked to these processes. Concerted action of the RNA/chromatin-modifying enzymes may play a crucial role in determining transcriptional output. Furthermore, non-coding RNAs appear to play a dual role, being targeting modules as well as encoding for target sites for complex recognition.
引用
收藏
页码：161 / 169
页数：9
相关论文
共 59 条
[1]   Chromodomains are protein-RNA interaction modules [J].
Akhtar, A ;
Zink, D ;
Becker, PB .
NATURE, 2000, 407 (6802) :405-409
[2]   Activation of transcription through histone H4 acetylation by MOF, an acetyltransferase essential for dosage compensation in Drosophila [J].
Akhtar, A ;
Becker, PB .
MOLECULAR CELL, 2000, 5 (02) :367-375
[3]   The histone H4 acetyltransferase MOF uses a C2HC zinc finger for substrate recognition [J].
Akhtar, A ;
Becker, PB .
EMBO REPORTS, 2001, 2 (02) :113-118
[4]   Genes expressed in neurons of adult male Drosophila [J].
Amrein, H ;
Axel, R .
CELL, 1997, 88 (04) :459-469
[5]   X-chromosome inactivation: Counting, choice and initiation [J].
Avner, P ;
Heard, E .
NATURE REVIEWS GENETICS, 2001, 2 (01) :59-67
[6]   Dosage compensation and chromatin structure in Drosophila [J].
Bashaw, GJ ;
Baker, BS .
CURRENT OPINION IN GENETICS & DEVELOPMENT, 1996, 6 (04) :496-501
[7]  
BASHAW GJ, 1995, DEVELOPMENT, V121, P3245
[8]   CONTROL OF X-CHROMOSOME TRANSCRIPTION BY THE MALELESS GENE IN DROSOPHILA [J].
BELOTE, JM ;
LUCCHESI, JC .
NATURE, 1980, 285 (5766) :573-575
[9]   Dosage-dependent gene regulation in multicellular eukaryotes: Implications for dosage compensation, aneuploid syndromes, and quantitative traits [J].
Birchler, JA ;
Bhadra, U ;
Bhadra, MP ;
Auger, DL .
DEVELOPMENTAL BIOLOGY, 2001, 234 (02) :275-288
[10]   ACETYLATED HISTONE H4 ON THE MALE X-CHROMOSOME IS ASSOCIATED WITH DOSAGE COMPENSATION IN DROSOPHILA [J].
BONE, JR ;
LAVENDER, J ;
RICHMAN, R ;
PALMER, MJ ;
TURNER, BM ;
KURODA, MI .
GENES & DEVELOPMENT, 1994, 8 (01) :96-117
123456