SYNTHESIS, CHARACTERIZATION AND BIOLOGICAL ACTIVITY OF VARIOUS SUBSTITUTED BENZOTHIAZOLE DERIVATIVES

被引：0

作者：

Kaur, Hemlata ^{[1
]}

Kumar, Sunil ^{[1
]}

Singh, Indu ^{[1
]}

Saxena, K. K. ^{[1
]}

Kumar, Ashok ^{[1
]}

机构：

[1] LLRM Med Coll, Div Med Chem, Dept Pharmacol, Meerut 250004, Uttar Pradesh, India

来源：

DIGEST JOURNAL OF NANOMATERIALS AND BIOSTRUCTURES | 2010年 / 5卷 / 01期

关键词：

Benzothiazoles; Indoles; Thiazolidinones; Oxadiazoles; Anti-inflammatory Activity; Analgesic activity; Antibacterial activity; Acute toxicity; ANTIINFLAMMATORY ACTIVITY; REVERSAL;

D O I：

暂无

中图分类号：

TB3 [工程材料学];

学科分类号：

0805 ; 080502 ;

摘要：

A series of 2-(benzo[d]thiazol-2-ylthio)-N-(2-oxoindolin-3-ylidene)acetohydrazide (3a-3g), 2-(benzo [d] thiazol-2-ylthio)-N-(2,4'-dioxospiro[indolin-3,2'-thiazolidin)-3'-yl)acetamide (4a-4g) and 2'-((benzo[d]thiazol-2-ylthio)methyl)spiro[indoline-3,5'-thiazolo[4,3-b][1,3,4]oxadiazol]-2-ones (5a-5g) have been synthesized and screened for their anti-inflammatory, analgesic and antibacterial activities. The most potent anti-inflammatory and antibacterial compound of this series was compound 5d and most potent analgesic compound was compound 5e. Structures of all the compounds were established by elemental and spectral (IR and H-1 NMR) analysis.

引用

页码：67 / U77

页数：11