SYNTHESIS, CHARACTERIZATION AND BIOLOGICAL ACTIVITY OF VARIOUS SUBSTITUTED BENZOTHIAZOLE DERIVATIVES

被引：0

作者：

Kaur, Hemlata ^{[1
]}

Kumar, Sunil ^{[1
]}

Singh, Indu ^{[1
]}

Saxena, K. K. ^{[1
]}

Kumar, Ashok ^{[1
]}

机构：

[1] LLRM Med Coll, Div Med Chem, Dept Pharmacol, Meerut 250004, Uttar Pradesh, India

来源：

DIGEST JOURNAL OF NANOMATERIALS AND BIOSTRUCTURES | 2010年 / 5卷 / 01期

关键词：

Benzothiazoles; Indoles; Thiazolidinones; Oxadiazoles; Anti-inflammatory Activity; Analgesic activity; Antibacterial activity; Acute toxicity; ANTIINFLAMMATORY ACTIVITY; REVERSAL;

D O I：

暂无

中图分类号：

TB3 [工程材料学];

学科分类号：

0805 ; 080502 ;

摘要：

A series of 2-(benzo[d]thiazol-2-ylthio)-N-(2-oxoindolin-3-ylidene)acetohydrazide (3a-3g), 2-(benzo [d] thiazol-2-ylthio)-N-(2,4'-dioxospiro[indolin-3,2'-thiazolidin)-3'-yl)acetamide (4a-4g) and 2'-((benzo[d]thiazol-2-ylthio)methyl)spiro[indoline-3,5'-thiazolo[4,3-b][1,3,4]oxadiazol]-2-ones (5a-5g) have been synthesized and screened for their anti-inflammatory, analgesic and antibacterial activities. The most potent anti-inflammatory and antibacterial compound of this series was compound 5d and most potent analgesic compound was compound 5e. Structures of all the compounds were established by elemental and spectral (IR and H-1 NMR) analysis.

引用

页码：67 / U77

页数：11

共 21 条

[1] Synthesis and biological evaluation of sulfonamide thiazole and benzothiazole derivatives as antimicrobial agents
Argyropoulou, Iro
Geronikaki, Athina
Vicini, Paola
Zani, Franca
[J]. ARKIVOC, 2009, : 89 - 102
[2] Bajaj K, 2003, INDIAN J CHEM B, V42, P1723
[3] BERKOWITZ BA, 1977, J PHARMACOL EXP THER, V203, P539
[4] STRUCTURE ACTIVITY RELATIONSHIPS OF DIHYDROFOLATE-REDUCTASE INHIBITORS
BLANEY, JM
HANSCH, C
SILIPO, C
VITTORIA, A
[J]. CHEMICAL REVIEWS, 1984, 84 (04) : 333 - 407
[5] Gadaginamath GS, 2003, INDIAN J CHEM B, V42, P2023
[6] Greenwood D., 1992, MED MICROBIOLOGY, V1
[7] GUALTIERE F, 1971, J MED CHEM, V14, P546
[8] Hadjipavlou-Litina D J, 1998, Drug Des Discov, V15, P199
[9] RHO-SIGMA-PI ANALYSIS . METHOD FOR CORRELATION OF BIOLOGICAL ACTIVITY + CHEMICAL STRUCTURE
HANSCH, C
FUJITA, T
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1964, 86 (08) : 1616 - &
[10] HARIB NJ, 1996, MED CHEM, V39, P4044

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