Dentipellin, a new antibiotic from culture broth of Dentipellis fragilis

被引：10

作者：

Ha, Lee Su ^{[1
,2
]}

Ki, Dae-Won ^{[1
,2
]}

Kim, Ji-Yul ^{[1
,2
]}

Choi, Dae-Cheol ^{[1
,2
]}

Lee, In-Kyoung ^{[1
,2
]}

Yun, Bong-Sik ^{[1
,2
]}

机构：

[1] Jeonbuk Natl Univ, Coll Environm & Bioresource Sci, Div Biotechnol, Iksan Si, South Korea

[2] Jeonbuk Natl Univ, Coll Environm & Bioresource Sci, Adv Inst Environm & Biosci, Iksan Si, South Korea

来源：

JOURNAL OF ANTIBIOTICS | 2021年 / 74卷 / 08期

关键词：

ERINACINE-C;

D O I：

10.1038/s41429-021-00426-1

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

In our effort to find antimicrobial agents from higher fungi, we isolated a new compound, dentipellin (1), along with three known glycosylated diterpenes, erinacines A-C (2-4) from culture broth of Dentipellis fragilis. Their chemical structures were determined by spectroscopic methods including NMR and mass measurements. These compounds exhibited weak antibacterial and antifungal activities.

引用

页码：538 / 541

页数：4

共 10 条

[1] Erinacine A and related cyathane diterpenoids: Molecular diversity and mechanisms underlying their neuroprotection and anticancer activities
Bailly, Christian
Gao, Jin-Ming
[J]. PHARMACOLOGICAL RESEARCH, 2020, 159
[2] ERINACINE-A, ERINACINE-B AND ERINACINE-C, STRONG STIMULATORS OF NERVE GROWTH-FACTOR (NGF)-SYNTHESIS, FROM THE MYCELIA OF HERICIUM ERINACEUM
KAWAGISHI, H
SHIMADA, A
SHIRAI, R
OKAMOTO, K
OJIMA, F
SAKAMOTO, H
ISHIGURO, Y
FURUKAWA, S
[J]. TETRAHEDRON LETTERS, 1994, 35 (10) : 1569 - 1572
[3] Compounds for dementia from Hericium erinaceum
Kawagishi, Hirokazu
Zhuang, Cun
[J]. DRUGS OF THE FUTURE, 2008, 33 (02) : 149 - 155
[4] Erinacine Q, a new erinacine from Hericium erinaceum, and its biosynthetic route to erinacine C in the basidiomycete
Kenmoku, H
Shimai, T
Toyomasu, T
Kato, N
Sassa, T
[J]. BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 2002, 66 (03) : 571 - 575
[5] Ma BingJi Ma BingJi, 2010, Mycology - An International Journal on Fungal Biology, V1, P92
[6] Antifungal Substances from Streptomyces sp A3265 Antagonistic to Plant Pathogenic Fungi
Nguyen Van Minh
Woo, E-Eum
Kim, Ji-Yul
Kim, Dae-Won
Hwang, Byung Soon
Lee, Yoon-Ju
Lee, In-Kyoung
Yun, Bong-Sik
[J]. MYCOBIOLOGY, 2015, 43 (03) : 333 - 338
[7] NIEMELA T, 1985, Karstenia, V25, P70
[8] Production of cyathane type secondary metabolites by submerged cultures of Hericium erinaceus and evaluation of their antibacterial activity by direct bioautography
T. Shen
G. Morlock
H. Zorn
[J]. Fungal Biology and Biotechnology, 2 (1)
[9] Rhizophins A and B, new sesquiterpenes from the culture broth of Coprinus rhizophorus
Woo, E-Eum
Ha, Lee Su
Kim, Ji-Yul
Lee, In-Kyoung
Yun, Bong-Sik
[J]. JOURNAL OF ANTIBIOTICS, 2020, 73 (03) : 175 - 178
[10] Mannonerolidol, a new nerolidol mannoside from culture broth of Schizophyllum commune
Woo, E-Eum
Kim, Ji-Yul
Kim, Jeong-Seon
Kwon, Soon-Wo
Lee, In-Kyoung
Yun, Bong-Sik
[J]. JOURNAL OF ANTIBIOTICS, 2019, 72 (03) : 178 - 180

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