A facile and one-pot synthesis of new tetrahydrobenzo[b]pyrans in water under microwave irradiation

被引：19

作者：

Khumalo, Mandlenkosi Robert ^{[1
]}

Maddila, Surya Narayana ^{[1
]}

Maddila, Suresh ^{[1
]}

Jonnalagadda, Sreekantha B. ^{[1
]}

机构：

[1] Univ KwaZulu Natal, Sch Chem & Phys, Westville Campus,Chiltern Hills, ZA-4000 Durban, South Africa

来源：

BMC CHEMISTRY | 2019年 / 13卷 / 01期

关键词：

Microwave irradiation; Multicomponent reactions; One-pot synthesis; Green synthesis; Benzopyrans; GREEN SYNTHESIS; MULTICOMPONENT SYNTHESIS; DERIVATIVES-SYNTHESIS; BIOLOGICAL-ACTIVITY; REUSABLE CATALYST; EFFICIENT;

D O I：

10.1186/s13065-019-0651-2

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Eleven new tetrahydrobenzo[b]pyran derivatives were synthesized via a three component reaction of different aromatic aldehydes, methyl cyanoacetate and 1,3-cyclohexadione, with water as solvent under catalyst-free microwave irradiation. The structures of all the new molecules were well analysed and their structures established by using various spectral techniques (H-1 NMR, C-13 NMR, N-15 NMR and HRMS). Various advantages of reported protocol are the ease of preparation, short reaction times (10 min), aqueous solvent and excellent yields (89-98%). Additionally, this method provides a clean access to the desired products by simple workup.

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页数：7

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