Signal transduction of heterotrimeric G proteins in lipid rafts

被引：0

作者：

Yuyama, Kohei ^{[1
]}

Sekino-Suzuki, Naoko ^{[1
]}

Kasahara, Kohji ^{[1
]}

机构：

[1] Tokyo Metropolitan Inst Med Sci, Biomembrane Signaling Project 2, Bunkyo Ku, Tokyo 1138613, Japan

来源：

TRENDS IN GLYCOSCIENCE AND GLYCOTECHNOLOGY | 2007年 / 19卷 / 105期

关键词：

lipid raft; caveolae; heterotrimeric G protein; signal transduction;

D O I：

10.4052/tigg.19.19

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Lipid rafts, glycosphingolipid and cholesterol-rich microdomains of plasma membrane, are implicated in signal transduction because a variety of signaling molecules, such as heterotrimeric G proteins and G protein-coupled receptors, are associated with them. Dynamic assemblies of lipid rafts with these molecules by extracellular events conduct signaling and sequentially regulate certain physical responses. This review focuses on the role of lipid rafts as a spatial compartment enriched in components of heterotrimeric G protein signaling.

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页码：19 / 27

页数：9

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