Hemin-assisted synthesis of peroxidase-like Fe-N-C nanozymes for detection of ascorbic acid-generating bio-enzymes

被引:230
作者
Liu, Wendong [1 ]
Chu, Lin [2 ]
Zhang, Chenghui [1 ]
Ni, Pengjuan [1 ]
Jiang, Yuanyuan [1 ]
Wang, Bo [1 ]
Lu, Yizhong [1 ]
Chen, Chuanxia [1 ]
机构
[1] Univ Jinan, Sch Mat Sci & Engn, Jinan 250022, Peoples R China
[2] Heze Med Coll, Heze 274000, Peoples R China
基金
中国国家自然科学基金;
关键词
Peroxidase nanozymes; Fe-N-C catalysts; Hemin; Ascorbic acid; Alkaline phosphatase; Colorimetric assay; EFFICIENT OXYGEN REDUCTION; CARBON FRAMEWORKS; POROUS CARBON; DOPED CARBON; ELECTROCATALYSTS; NANOCOMPOSITES; NANOPARTICLES; NANOSHEETS; CATALYSTS;
D O I
10.1016/j.cej.2021.128876
中图分类号
X [环境科学、安全科学];
学科分类号
08 ; 0830 ;
摘要
Revealing the relationship between composition and enzyme-like activities is essential for the rational designs of nanozymes and related assays with improved performances. Here, a series of Fe-N co-doped porous carbon (Fe-NC) nanozymes containing different Fe contents have been successfully prepared by facilely pyrolyzing hemin trapped zeolitic-imidazolate-frameworks (Hemin@ZIF-8). The special doping agent hemin will endow Fe-N-C with exceptionally high peroxidase-mimetic activities due to the hierarchically porous structure, high specific surface area, and high dispersed Fe-Nx sites. Notably, the optimal Fe55-N-C nanozymes are used to detect bioenzymes, by taking alkaline phosphatase (ALP) as a model, based on the inhibition of nanozymatic activity by ascorbic acid (AA). A linear activity range of 0.05?20 U/L is obtained with a low detection limit of 0.03 U/L, which is superior to the most published optical ALP assays. This work provides not only a new method for the design of the transition metal-N-C nanozyme with enhanced peroxidase-like activity but also a promising strategy for the detection of ascorbic acid-generating bio-enzymes with the assistance of specific substrates.
引用
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页数:10
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