Epigenetics and Inflammation in Diabetic Nephropathy

被引：33
|
作者：
Shao, Bao-Yi [1 ]
Zhang, Shao-Fei [2 ]
Li, Hai-Di [2 ]
Meng, Xiao-Ming [2 ]
Chen, Hai-Yong [3 ,4 ]
机构：
[1] Univ Hong Kong, Li Ka Shing Fac Med, Hong Kong, Peoples R China
[2] Anhui Med Univ, Sch Pharm, Anhui Inst Innovat Drugs, Inflammat & Immune Mediated Dis Lab Anhui Prov, Hefei, Peoples R China
[3] Univ Hong Kong, Sch Chinese Med, Hong Kong, Peoples R China
[4] Univ Hong Kong, Dept Chinese Med, Shenzhen Hosp, Shenzhen, Peoples R China
来源：
FRONTIERS IN PHYSIOLOGY | 2021年 / 12卷
关键词：
diabetic nephropathy; epigenetics; DNA methylation; histone modifications; non-coding RNAs; inflammation; THIOREDOXIN-INTERACTING PROTEIN; GLUCOSE-INDUCED INFLAMMATION; URINARY ALBUMIN EXCRETION; RENAL FIBROSIS; GENE-EXPRESSION; KIDNEY-DISEASE; DB/DB MICE; MESENCHYMAL TRANSITION; HISTONE METHYLATION; OXIDATIVE STRESS;
D O I：
10.3389/fphys.2021.649587
中图分类号：
Q4 [生理学];
学科分类号：
071003 ;
摘要：
Diabetic nephropathy (DN) leads to high morbidity and disability. Inflammation plays a critical role in the pathogenesis of DN, which involves renal cells and immune cells, the microenvironment, as well as extrinsic factors, such as hyperglycemia, chemokines, cytokines, and growth factors. Epigenetic modifications usually regulate gene expression via DNA methylation, histone modification, and non-coding RNAs without altering the DNA sequence. During the past years, numerous studies have been published to reveal the mechanisms of epigenetic modifications that regulate inflammation in DN. This review aimed to summarize the latest evidence on the interplay of epigenetics and inflammation in DN, and highlight the potential targets for treatment and diagnosis of DN.
引用
收藏
页数：14
相关论文
共 50 条
  • [41] Complement C5a inhibition moderates lipid metabolism and reduces tubulointerstitial fibrosis in diabetic nephropathy
    Yiu, Wai Han
    Li, Rui Xi
    Wong, Dickson W. L.
    Wu, Hao Jia
    Chan, Kam Wa
    Chan, Loretta Y. Y.
    Leung, Joseph C. K.
    Lai, Kar Neng
    Sacks, Steven H.
    Zhou, Wuding
    Tang, Sydney C. W.
    NEPHROLOGY DIALYSIS TRANSPLANTATION, 2018, 33 (08) : 1323 - 1332
  • [42] Metabolic rewiring and epigenetic reprogramming in leptin receptor-deficient db/db diabetic nephropathy mice
    Sarwar, Md. Shahid
    Cheng, David
    Peter, Rebecca Mary
    Shannar, Ahmad
    Chou, Pochung
    Wang, Lujing
    Wu, Renyi
    Sargsyan, Davit
    Goedken, Michael
    Wang, Yujue
    Su, Xiaoyang
    Hart, Ronald P.
    Kong, Ah-Ng
    EUROPEAN JOURNAL OF PHARMACOLOGY, 2023, 953
  • [43] Tripterygium and its extracts for diabetic nephropathy: Efficacy and pharmacological mechanisms
    Huang, Wei-jun
    Liu, Wei-jing
    Xiao, Yong-hua
    Zheng, Hui-juan
    Xiao, Yao
    Jia, Qi
    Jiang, Han-xue
    Zhu, Ze-bing
    Xia, Chen-hui
    Han, Xue-ting
    Sun, Rui-xi
    Nan, He
    Feng, Zheng-dong
    Wang, Shi-dong
    Zhao, Jin-xi
    BIOMEDICINE & PHARMACOTHERAPY, 2020, 121
  • [44] Targeting epigenetics in diabetic cardiomyopathy: Therapeutic potential of flavonoids
    Zhou, Yutong
    Suo, Wendong
    Zhang, Xinai
    Yang, Yanan
    Zhao, Weizhe
    Li, Hong
    Ni, Qing
    BIOMEDICINE & PHARMACOTHERAPY, 2023, 157
  • [45] Contribution of epigenetics in diabetic retinopathy
    Kowluru, Renu A.
    Mishra, Manish
    SCIENCE CHINA-LIFE SCIENCES, 2015, 58 (06) : 556 - 563
  • [46] Effect of exenatide intervention on inflammation and oxidative stress levels in patients with diabetic nephropathy
    Lu, Yanyan
    Tao, Guilu
    Zhong, Cundi
    Wang, Yuxuan
    Yin, Xiaohong
    INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE, 2020, 13 (10): : 7193 - 7202
  • [47] Epigenetics in the development of diabetic cardiomyopathy
    Pepin, Mark E.
    Wende, Adam R.
    EPIGENOMICS, 2019, 11 (05) : 469 - 472
  • [48] CDK9 inhibition improves diabetic nephropathy by reducing inflammation in the kidneys
    Yang, Xiaojing
    Luo, Wu
    Li, Li
    Hu, Xiang
    Xu, Mingjiang
    Wang, Yi
    Feng, Jianpeng
    Qian, Jianchang
    Guan, Xinfu
    Zhao, Yunjie
    Liang, Guang
    TOXICOLOGY AND APPLIED PHARMACOLOGY, 2021, 416
  • [49] Lycium chinense leaves extract ameliorates diabetic nephropathy by suppressing hyperglycemia mediated renal oxidative stress and inflammation
    Olatunji, Opeyemi Joshua
    Chen, Hongxia
    Zhou, Yifeng
    BIOMEDICINE & PHARMACOTHERAPY, 2018, 102 : 1145 - 1151
  • [50] Epac activation ameliorates tubulointerstitial inflammation in diabetic nephropathy
    Wen-xia Yang
    Yu Liu
    Shu-min Zhang
    Hua-fen Wang
    Yi-fei Liu
    Jia-lu Liu
    Xiao-hui Li
    Meng-ru Zeng
    Yu-zhang Han
    Fu-you Liu
    Lin Sun
    Li Xiao
    Acta Pharmacologica Sinica, 2022, 43 : 659 - 671
12345