Epigenetics and Inflammation in Diabetic Nephropathy

被引：40
作者：
Shao, Bao-Yi [1 ]
Zhang, Shao-Fei [2 ]
Li, Hai-Di [2 ]
Meng, Xiao-Ming [2 ]
Chen, Hai-Yong [3 ,4 ]
机构：
[1] Univ Hong Kong, Li Ka Shing Fac Med, Hong Kong, Peoples R China
[2] Anhui Med Univ, Sch Pharm, Anhui Inst Innovat Drugs, Inflammat & Immune Mediated Dis Lab Anhui Prov, Hefei, Peoples R China
[3] Univ Hong Kong, Sch Chinese Med, Hong Kong, Peoples R China
[4] Univ Hong Kong, Dept Chinese Med, Shenzhen Hosp, Shenzhen, Peoples R China
来源：
FRONTIERS IN PHYSIOLOGY | 2021年 / 12卷
关键词：
diabetic nephropathy; epigenetics; DNA methylation; histone modifications; non-coding RNAs; inflammation; THIOREDOXIN-INTERACTING PROTEIN; GLUCOSE-INDUCED INFLAMMATION; URINARY ALBUMIN EXCRETION; RENAL FIBROSIS; GENE-EXPRESSION; KIDNEY-DISEASE; DB/DB MICE; MESENCHYMAL TRANSITION; HISTONE METHYLATION; OXIDATIVE STRESS;
D O I：
10.3389/fphys.2021.649587
中图分类号：
Q4 [生理学];
学科分类号：
071003 ;
摘要：
Diabetic nephropathy (DN) leads to high morbidity and disability. Inflammation plays a critical role in the pathogenesis of DN, which involves renal cells and immune cells, the microenvironment, as well as extrinsic factors, such as hyperglycemia, chemokines, cytokines, and growth factors. Epigenetic modifications usually regulate gene expression via DNA methylation, histone modification, and non-coding RNAs without altering the DNA sequence. During the past years, numerous studies have been published to reveal the mechanisms of epigenetic modifications that regulate inflammation in DN. This review aimed to summarize the latest evidence on the interplay of epigenetics and inflammation in DN, and highlight the potential targets for treatment and diagnosis of DN.
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页数：14
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共 175 条
[71]  
Li SH, 2020, CURRENT TRENDS AND FUTURE DEVELOPMENTS ON (BIO-) MEMBRANES: REVERSE AND FORWARD OSMOSIS: PRINCIPLES, APPLICATIONS, ADVANCES, P261, DOI 10.1016/B978-0-12-816777-9.00011-3
[72]   Long noncoding RNA MALAT1 regulates renal tubular epithelial pyroptosis by modulated miR-23c targeting of ELAVL1 in diabetic nephropathy [J].
Li, Xue ;
Zeng, Li ;
Cao, Chuanwu ;
Lu, Chenhui ;
Lian, Weishuai ;
Han, Jianhong ;
Zhang, Xiaojun ;
Zhang, Jing ;
Tang, Tao ;
Li, Maoquan .
EXPERIMENTAL CELL RESEARCH, 2017, 350 (02) :327-335
[73]   Role of the histone H3 lysine 4 methyltransferase, SET7/9, in the regulation of NF-κB-dependent inflammatory genes -: Relevance to diabetes and inflammation [J].
Li, Yan ;
Reddy, Marpadga A. ;
Miao, Feng ;
Shanmugam, Narkunaraja ;
Yee, Jiing-Kuan ;
Hawkins, David ;
Ren, Bing ;
Natarajan, Rama .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2008, 283 (39) :26771-26781
[74]   Diabetic nephropathy - complications and treatment [J].
Lim, Andy K. H. .
INTERNATIONAL JOURNAL OF NEPHROLOGY AND RENOVASCULAR DISEASE, 2014, 7 :361-381
[75]   New Insights into the Mechanisms of Pyroptosis and Implications for Diabetic Kidney Disease [J].
Lin, Jinwen ;
Cheng, Ao ;
Cheng, Kai ;
Deng, Qingwei ;
Zhang, Shouzan ;
Lan, Zehao ;
Wang, Weidong ;
Chen, Jianghua .
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2020, 21 (19) :1-23
[76]   Global, regional, and national burden and trend of diabetes in 195 countries and territories: an analysis from 1990 to 2025 [J].
Lin, Xiling ;
Xu, Yufeng ;
Pan, Xiaowen ;
Xu, Jingya ;
Ding, Yue ;
Sun, Xue ;
Song, Xiaoxiao ;
Ren, Yuezhong ;
Shan, Peng-Fei .
SCIENTIFIC REPORTS, 2020, 10 (01)
[77]   C-reactive protein promotes diabetic kidney disease in a mouse model of type 1 diabetes [J].
Liu, F. ;
Chen, H. Y. ;
Huang, X. R. ;
Chung, A. C. K. ;
Zhou, L. ;
Fu, P. ;
Szalai, A. J. ;
Lan, H. Y. .
DIABETOLOGIA, 2011, 54 (10) :2713-2723
[78]   Silencing of Histone Deacetylase 9 Expression in Podocytes Attenuates Kidney Injury in Diabetic Nephropathy [J].
Liu, Feng ;
Zong, Ming ;
Wen, Xiaofei ;
Li, Xuezhu ;
Wang, Jun ;
Wang, Yi ;
Jiang, Wei ;
Li, Xiaojun ;
Guo, Zhongliang ;
Qi, Hualin .
SCIENTIFIC REPORTS, 2016, 6
[79]   Real-time visualization of clustering and intracellular transport of gold nanoparticles by correlative imaging [J].
Liu, Mengmeng ;
Li, Qian ;
Liang, Le ;
Li, Jiang ;
Wang, Kun ;
Li, Jiajun ;
Lv, Min ;
Chen, Nan ;
Song, Haiyun ;
Lee, Joon ;
Shi, Jiye ;
Wang, Lihua ;
Lal, Ratnesh ;
Fan, Chunhai .
NATURE COMMUNICATIONS, 2017, 8
[80]   Interactions Among Non-Coding RNAs in Diabetic Nephropathy [J].
Loganathan, Tamil Selvi ;
Sulaiman, Siti Aishah ;
Murad, Nor Azian Abdul ;
Shah, Shamsul Azhar ;
Gafor, Abdul Halim Abdul ;
Jamal, Rahman ;
Abdullah, Noraidatulakma .
FRONTIERS IN PHARMACOLOGY, 2020, 11
3456789101112