Epigenetics and Inflammation in Diabetic Nephropathy

被引：40
作者：
Shao, Bao-Yi [1 ]
Zhang, Shao-Fei [2 ]
Li, Hai-Di [2 ]
Meng, Xiao-Ming [2 ]
Chen, Hai-Yong [3 ,4 ]
机构：
[1] Univ Hong Kong, Li Ka Shing Fac Med, Hong Kong, Peoples R China
[2] Anhui Med Univ, Sch Pharm, Anhui Inst Innovat Drugs, Inflammat & Immune Mediated Dis Lab Anhui Prov, Hefei, Peoples R China
[3] Univ Hong Kong, Sch Chinese Med, Hong Kong, Peoples R China
[4] Univ Hong Kong, Dept Chinese Med, Shenzhen Hosp, Shenzhen, Peoples R China
来源：
FRONTIERS IN PHYSIOLOGY | 2021年 / 12卷
关键词：
diabetic nephropathy; epigenetics; DNA methylation; histone modifications; non-coding RNAs; inflammation; THIOREDOXIN-INTERACTING PROTEIN; GLUCOSE-INDUCED INFLAMMATION; URINARY ALBUMIN EXCRETION; RENAL FIBROSIS; GENE-EXPRESSION; KIDNEY-DISEASE; DB/DB MICE; MESENCHYMAL TRANSITION; HISTONE METHYLATION; OXIDATIVE STRESS;
D O I：
10.3389/fphys.2021.649587
中图分类号：
Q4 [生理学];
学科分类号：
071003 ;
摘要：
Diabetic nephropathy (DN) leads to high morbidity and disability. Inflammation plays a critical role in the pathogenesis of DN, which involves renal cells and immune cells, the microenvironment, as well as extrinsic factors, such as hyperglycemia, chemokines, cytokines, and growth factors. Epigenetic modifications usually regulate gene expression via DNA methylation, histone modification, and non-coding RNAs without altering the DNA sequence. During the past years, numerous studies have been published to reveal the mechanisms of epigenetic modifications that regulate inflammation in DN. This review aimed to summarize the latest evidence on the interplay of epigenetics and inflammation in DN, and highlight the potential targets for treatment and diagnosis of DN.
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页数：14
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共 175 条
[111]   Changes of serum Mir-217 and the correlation with the severity in type 2 diabetes patients with different stages of diabetic kidney disease [J].
Shao, Ying ;
Ren, Huiwen ;
Lv, Chuan ;
Ma, Xiaoyu ;
Wu, Can ;
Wang, Qiuyue .
ENDOCRINE, 2017, 55 (01) :139-147
[112]   Mir-217 promotes inflammation and fibrosis in high glucose cultured rat glomerular mesangial cells via Sirt1/HIF-1α signaling pathway [J].
Shao, Ying ;
Lv, Chuan ;
Wu, Can ;
Zhou, Yuehong ;
Wang, Qiuyue .
DIABETES-METABOLISM RESEARCH AND REVIEWS, 2016, 32 (06) :534-543
[113]   Smad3 deficiency promotes beta cell proliferation and function in db/db mice via restoring Pax6 expression [J].
Sheng, Jingyi ;
Wang, Li ;
Tang, Patrick Ming-Kuen ;
Wang, Hong-Lian ;
Li, Jian-Chun ;
Xu, Bi-Hua ;
Xue, Vivian Weiwen ;
Tan, Rui-Zhi ;
Jin, Nana ;
Chan, Ting-Fung ;
Huang, Xiao-Ru ;
Ma, Ronald C. W. ;
Lan, Hui-Yao .
THERANOSTICS, 2021, 11 (06) :2845-2859
[114]   Omentin-1 protects renal function of mice with type 2 diabetic nephropathy via regulating miR-27a-Nrf2/Keap1 axis [J].
Song, Juan ;
Zhang, Hongxia ;
Sun, Yanni ;
Guo, Ruimin ;
Zhong, Dongxiang ;
Xu, Runxi ;
Song, Meng .
BIOMEDICINE & PHARMACOTHERAPY, 2018, 107 :440-446
[115]   An expanding universe of noncoding RNAs [J].
Storz, G .
SCIENCE, 2002, 296 (5571) :1260-1263
[116]   Downregulation of MiR-218 can alleviate high-glucose-induced renal proximal tubule injury by targeting GPRC5A [J].
Su, Shan-Shan ;
Li, Bao-Peng ;
Li, Chun-Lin ;
Xiu, Fang-Rui ;
Wang, Dong-Yan ;
Zhang, Fa-Rong .
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 2020, 84 (06) :1123-1130
[117]   Pentraxin-3 Attenuates Renal Damage in Diabetic Nephropathy by Promoting M2 Macrophage Differentiation [J].
Sun, Huaibin ;
Tian, Jun ;
Xian, Wanhua ;
Xie, Tingting ;
Yang, Xiangdong .
INFLAMMATION, 2015, 38 (05) :1739-1747
[118]   MiR-325-3p inhibits renal inflammation and fibrosis by targeting CCL19 in diabetic nephropathy [J].
Sun, Jiping ;
Wang, Jing ;
Lu, Wanhong ;
Xie, Liyi ;
Lv, Jing ;
Li, Huixian ;
Yang, Shifeng .
CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY, 2020, 47 (11) :1850-1860
[119]   Novel lncRNA Erbb4-IR Promotes Diabetic Kidney Injury in db/db Mice by Targeting miR-29b [J].
Sun, Si F. ;
Tang, Patrick M. K. ;
Feng, Min ;
Xiao, Jun ;
Huang, Xiao R. ;
Li, Ping ;
Ma, Ronald C. W. ;
Lan, Hui Y. .
DIABETES, 2018, 67 (04) :731-744
[120]   MicroRNA-544 attenuates diabetic renal injury via suppressing glomerulosclerosis and inflammation by targeting FASN [J].
Sun, Tao ;
Liu, Yang ;
Liu, Lingyun ;
Ma, Fuzhe .
GENE, 2020, 723
78910111213141516