Epigenetics and Inflammation in Diabetic Nephropathy

被引：40

作者：

Shao, Bao-Yi ^{[1
]}

Zhang, Shao-Fei ^{[2
]}

Li, Hai-Di ^{[2
]}

Meng, Xiao-Ming ^{[2
]}

Chen, Hai-Yong ^{[3
,4
]}

机构：

[1] Univ Hong Kong, Li Ka Shing Fac Med, Hong Kong, Peoples R China

[2] Anhui Med Univ, Sch Pharm, Anhui Inst Innovat Drugs, Inflammat & Immune Mediated Dis Lab Anhui Prov, Hefei, Peoples R China

[3] Univ Hong Kong, Sch Chinese Med, Hong Kong, Peoples R China

[4] Univ Hong Kong, Dept Chinese Med, Shenzhen Hosp, Shenzhen, Peoples R China

来源：

FRONTIERS IN PHYSIOLOGY | 2021年 / 12卷

关键词：

diabetic nephropathy; epigenetics; DNA methylation; histone modifications; non-coding RNAs; inflammation; THIOREDOXIN-INTERACTING PROTEIN; GLUCOSE-INDUCED INFLAMMATION; URINARY ALBUMIN EXCRETION; RENAL FIBROSIS; GENE-EXPRESSION; KIDNEY-DISEASE; DB/DB MICE; MESENCHYMAL TRANSITION; HISTONE METHYLATION; OXIDATIVE STRESS;

D O I：

10.3389/fphys.2021.649587

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

Diabetic nephropathy (DN) leads to high morbidity and disability. Inflammation plays a critical role in the pathogenesis of DN, which involves renal cells and immune cells, the microenvironment, as well as extrinsic factors, such as hyperglycemia, chemokines, cytokines, and growth factors. Epigenetic modifications usually regulate gene expression via DNA methylation, histone modification, and non-coding RNAs without altering the DNA sequence. During the past years, numerous studies have been published to reveal the mechanisms of epigenetic modifications that regulate inflammation in DN. This review aimed to summarize the latest evidence on the interplay of epigenetics and inflammation in DN, and highlight the potential targets for treatment and diagnosis of DN.

引用

页数：14

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