Persistent cellular immunity to SARS-CoV-2 infection

被引：86

作者：

Breton, Gaelle ^{[1
]}

Mendoza, Pilar ^{[1
]}

Hagglof, Thomas ^{[1
]}

Oliveira, Thiago Y. ^{[1
]}

Schaefer-Babajew, Dennis ^{[1
]}

Gaebler, Christian ^{[1
]}

Turroja, Martina ^{[1
]}

Hurley, Arlene ^{[2
]}

Caskey, Marina ^{[1
]}

Nussenzweig, Michel C. ^{[1
,3
]}

机构：

[1] Rockefeller Univ, Lab Mol Immunol, 1230 York Ave, New York, NY 10021 USA

[2] Rockefeller Univ, Hosp Program Direct, 1230 York Ave, New York, NY 10021 USA

[3] Howard Hughes Med Inst, Baltimore, MD USA

来源：

JOURNAL OF EXPERIMENTAL MEDICINE | 2021年 / 218卷 / 04期

基金：

美国国家卫生研究院; 瑞典研究理事会;

关键词：

ACUTE RESPIRATORY SYNDROME; CD8(+) T-CELLS; MEMORY B-CELLS; PROTECTION; RESPONSES; COVID-19;

D O I：

10.1084/jem.20202515

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

SARS-CoV-2 is responsible for an ongoing pandemic that has affected millions of individuals around the globe. To gain further understanding of the immune response in recovered individuals, we measured T cell responses in paired samples obtained an average of 1.3 and 6.1 mo after infection from 41 individuals. The data indicate that recovered individuals show persistent polyfunctional SARS-CoV-2 antigen-specific memory that could contribute to rapid recall responses. Recovered individuals also show enduring alterations in relative overall numbers of CD4(+) and CD8(+) memory T cells, including expression of activation/exhaustion markers, and cell division.

引用

页数：18

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