Characteristics of highly myopic eyes - The Beijing Eye Study

Objective: To evaluate factors associated with high myopia (defined as a myopic refractive error exceeding -8 diopters) in a population-based study. Design: Population-based prevalence study. Participants: The Beijing Eye Study included 4439 participants from among 5324 individuals from a rural area and an urban region of Greater Beijing, >= 40 years old and invited to participate (response rate, 83.4%). Methods: Interview and detailed ophthalmic examination. Main Outcome Measures: Refractive error, microvascular retinal abnormalities, optic disc morphometry, amount of cataract, and age-related macular changes. Results: Fundus photographs and data for refractive error were available for 4319 participants (97.3%; 8484 eyes). In binary logistic regression analysis, prevalence of high myopia was significantly associated with low best-corrected visual acuity (P < 0.001; 95% confidence interval [CI], 0.15-0.40), large optic disc size (P < 0.001; 95% Cl, 1.64-2.25), large size of 0 zone (P = 0.31; 95% Cl, 1.45-1.75) and a zone of peripapillary atrophy (P < 0.001; 95% Cl, 1.20-1.58), and lower macular drusen count (P = 0.020; 95% Cl, 0.81-0.98). The highly myopic group had a smaller mean size of macular drusen (P = 0.03; 95% Cl, 0.02-0.26) and a smaller area covered by drusen (P = 0.01; 95% Cl, 0.03-0.22). In the highly myopic group, the predominant drusen type was significantly (P = 0.01; 95% Cl, 0.05-0.41) more often the hard distinct drusen type than the soft drusen type, and visual field defects were significantly more common (P < 0.001; odds ratio [OR], 24.0; 95% Cl, 13.9-41.4) and larger (P < 0.001; 95% Cl, -1.67 to -1.13). The frequencies of early macular degeneration (P = 0.03; OR, 3.0; 95% Cl, 1.21-7.51) and late macular degeneration (P < 0.001; OR, 6.33) were significantly lower in the highly myopic group than in the non-highly myopic group. High myopia was not significantly associated with gender (P = 0.18; 95% Cl, 0.76-1.05), focal arteriolar thinning (P > 0.35), arteriolar sheathing (P > 0.45), arteriovenous crossing abnormalities (P > 0.20), self-reported diagnosis of diabetes mellitus (P = 0.54; OR, 1.36; 95% Cl, 0.48-3.80), or arterial hypertension (P = 0.34; OR, 0.66; 95% Cl, 0.32-1.34). Conclusions: In the adult Chinese population, high myopia is associated with a lower number, smaller, size and less advanced type of macular drusen, a larger optic nerve head, and decreased best-corrected visual acuity. The risk of early and late macular degeneration was lower for highly myopic participants than for non-highly myopic participants.