Genetics of the Restless Legs Syndrome

被引：0
作者：
Winkelmann, J. [1 ,2 ]
机构：
[1] Tech Univ Munich, Klinikum Rechts Isar, Neurol Klin, Helmholtz Zentrum Munchen, D-81675 Munich, Germany
[2] Tech Univ Munich, Klinikum Rechts Isar, Inst Human Genet, Helmholtz Zentrum Munchen, D-81675 Munich, Germany
来源：
AKTUELLE NEUROLOGIE | 2009年 / 36卷 / 10期
关键词：
restless legs syndrome; sleep; genetics; SUSCEPTIBILITY LOCUS; ASSOCIATION; POPULATION; RISK; PREVALENCE; MAPS;
D O I：
10.1055/s-0029-1223407
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
In genome-wide association studies genetic risk variations for the restless legs syndrome (RLS) have been identified in the genes MEIS1, BTBD9, PTPRD and LBXCOR1/MAP2K5 genes. Carriers of one risk allele have an increased risk to suffer from RLS. Further genetic and/or non-genetic or environmental factors must additionally be present for a person to be afflicted by RLS. It is, however, not known which specific factors are involved in this process. The identified genes are involved in the development of the central nervous system. Further research is needed to show whether RLS has components of a neurological development disorder or whether the RLS genes in the adult CNS have completely different functions in relation to RLS and in the adult CNS.
引用
收藏
页码：524 / 527
页数：4
相关论文
共 27 条
[1]   Restless legs syndrome: diagnostic criteria, special considerations, and epidemiology - A report from the restless legs syndrome diagnosis and epidemiology workshop at the National Institutes of Health [J].
Allen, RP ;
Picchietti, D ;
Hening, WA ;
Trenkwalder, C ;
Walters, AS ;
Montplaisi, J .
SLEEP MEDICINE, 2003, 4 (02) :101-119
[2]   Restless legs syndrome prevalence and impact - REST general population study [J].
Allen, RP ;
Walters, AS ;
Montplaisir, J ;
Hening, W ;
Myers, A ;
Bell, TJ ;
Ferini-Strambi, L .
ARCHIVES OF INTERNAL MEDICINE, 2005, 165 (11) :1286-1292
[3]   Unraveling the crucial roles of Meis1 in leukemogenesis and normal hematopoiesis [J].
Argiropoulos, Bob ;
Yung, Eric ;
Humphries, R. Keith .
GENES & DEVELOPMENT, 2007, 21 (22) :2845-2849
[4]   Sex and the risk of restless legs syndrome in the general population [J].
Berger, K ;
Luedemann, J ;
Trenkwalder, C ;
Ulrich, J ;
Kessler, C .
ARCHIVES OF INTERNAL MEDICINE, 2004, 164 (02) :196-202
[5]   A message of restless legs on ethnicity [J].
Berger, Klaus .
SLEEP MEDICINE, 2006, 7 (08) :597-598
[6]   Autosomal dominant restless legs syndrome maps on chromosome 14q [J].
Bonati, MT ;
Ferini-Strambi, L ;
Aridon, P ;
Oldani, A ;
Zucconi, M ;
Casari, G .
BRAIN, 2003, 126 :1485-1492
[7]  
Capecchi MR, 1997, COLD SPRING HARB SYM, V62, P273, DOI 10.1101/SQB.1997.062.01.034
[8]   Genomewide linkage scan identifies a novel susceptibility locus for restless legs syndrome on chromosome 9p [J].
Chen, SH ;
Ondo, WG ;
Rao, SQ ;
Li, L ;
Chen, QY ;
Wang, Q .
AMERICAN JOURNAL OF HUMAN GENETICS, 2004, 74 (05) :876-885
[9]   A Hox regulatory network establishes motor neuron pool identity and target-muscle connectivity [J].
Dasen, JS ;
Tice, BC ;
Brenner-Morton, S ;
Jessell, TM .
CELL, 2005, 123 (03) :477-491
[10]   Identification of a major susceptibility locus for restless legs syndrome on chromosome 12q [J].
Desautels, A ;
Turecki, G ;
Montplaisir, J ;
Sequeira, A ;
Verner, A ;
Rouleau, GA .
AMERICAN JOURNAL OF HUMAN GENETICS, 2001, 69 (06) :1266-1270
123