Cancer cell nucleus-targeting nanocomposites for advanced tumor therapeutics

被引:226
作者
Pan, Limin [1 ]
Liu, Jianan [1 ]
Shi, Jianlin [1 ]
机构
[1] Chinese Acad Sci, Shanghai Inst Ceram, State Key Lab High Performance Ceram & Superfine, 1295 Ding Xi Rd, Shanghai 200050, Peoples R China
基金
中国国家自然科学基金;
关键词
DRUG-DELIVERY; PHOTODYNAMIC THERAPY; MULTIDRUG-RESISTANCE; GOLD NANOPARTICLES; SIZE; PEPTIDE; SYSTEM; PHOTOSENSITIZER; DESIGN;
D O I
10.1039/c8cs00081f
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Tumor therapeutic efficacy is determined, to a great extent, by the delivery efficiency of therapeutic drugs to their final targets. The cell nucleus has been proven to be the main interaction site for most therapeutic agents such as anticancer drugs, genes, free radicals, and heat. Therefore, it is highly expected that cell nucleus-targeting or nuclear membrane-penetrating nanotherapeutics would provide a more effective strategy than ordinary cell membrane-targeting ones for benefiting precise nanomedicine in humans' battles against cancer. This tutorial review presents a summary of the most recent progress achieved in the design, synthesis, and application of cell nucleus-targeting nanotherapeutics. We first discuss a number of design principles involved in cell nucleus-targeting nanotherapeutics, including size control, shape regulation, and surface modification. Next, we demonstrate the diverse applications of cell nucleus-targeting nanotherapeutics ranging from chemotherapy, gene therapy, photodynamic therapy, photothermal therapy to synergistic therapy. Moreover, a number of typical nanotherapeutics designed for enhanced therapeutic efficacy by targeting other subcellular organelles (such as mitochondria, lysosomes, and endoplasmic reticulum) are also briefly discussed. Finally, perspectives and challenges in this research field are proposed, in the hope of accelerating their translation into the clinic.
引用
收藏
页码:6930 / 6946
页数:17
相关论文
共 51 条
[1]   A Real-Time Surface Enhanced Raman Spectroscopy Study of Plasmonic Photothermal Cell Death Using Targeted Gold Nanoparticles [J].
Aioub, Mena ;
El-Sayed, Mostafa A. .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2016, 138 (04) :1258-1264
[2]   Nuclear localization signal peptides enhance cationic liposome-mediated gene therapy [J].
Aronsohn, AI ;
Hughes, JA .
JOURNAL OF DRUG TARGETING, 1998, 5 (03) :163-169
[3]  
Ashley CE, 2011, NAT MATER, V10, P389, DOI [10.1038/NMAT2992, 10.1038/nmat2992]
[4]   Lysosome-Targeting Amplifiers of Reactive Oxygen Species as Anticancer Prodrugs [J].
Daum, Steffen ;
Reshetnikov, M. S. Viktor ;
Sisa, Miroslav ;
Dumych, Tetyana ;
Lootsik, Maxim D. ;
Bilyy, Rostyslav ;
Bila, Evgenia ;
Janko, Christina ;
Alexiou, Christoph ;
Herrmann, Martin ;
Sellner, Leopold ;
Mokhir, Andriy .
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2017, 56 (49) :15545-15549
[5]   Intranuclear biophotonics by smart design of nuclear-targeting photo-/radio-sensitizers co-loaded upconversion nanoparticles [J].
Fan, Wenpei ;
Shen, Bo ;
Bu, Wenbo ;
Zheng, Xiangpeng ;
He, Qianjun ;
Cui, Zhaowen ;
Ni, Dalong ;
Zhao, Kuaile ;
Zhang, Shengjian ;
Shi, Jianlin .
BIOMATERIALS, 2015, 69 :89-98
[6]   Design of an intelligent sub-50 nm nuclear-targeting nanotheranostic system for imaging guided intranuclear radiosensitization [J].
Fan, Wenpei ;
Shen, Bo ;
Bu, Wenbo ;
Zheng, Xiangpeng ;
He, Qianjun ;
Cui, Zhaowen ;
Zhao, Kuaile ;
Zhang, Shengjian ;
Shi, Jianlin .
CHEMICAL SCIENCE, 2015, 6 (03) :1747-1753
[7]   pH-activated size reduction of large compound nanoparticles for in vivo nucleus-targeted drug delivery [J].
Fan, Yanbin ;
Li, Chunyan ;
Li, Fuyou ;
Chen, Daoyong .
BIOMATERIALS, 2016, 85 :30-39
[8]   Nuclear transport: Target for therapy [J].
Faustino, R. S. ;
Nelson, T. J. ;
Terzic, A. ;
Perez-Terzic, C. .
CLINICAL PHARMACOLOGY & THERAPEUTICS, 2007, 81 (06) :880-886
[9]   Acidity-Triggered Tumor-Targeted Chimeric Peptide for Enhanced Intra-Nuclear Photodynamic Therapy [J].
Han, Kai ;
Zhang, Wei-Yun ;
Zhang, Jin ;
Lei, Qi ;
Wang, Shi-Bo ;
Liu, Jia-Wei ;
Zhang, Xian-Zheng ;
Han, He-You .
ADVANCED FUNCTIONAL MATERIALS, 2016, 26 (24) :4351-4361
[10]   Dual-pH Sensitive Charge-Reversal Polypeptide Micelles for Tumor-Triggered Targeting Uptake and Nuclear Drug Delivery [J].
Han, Shi-Song ;
Li, Ze-Yong ;
Zhu, Jing-Yi ;
Han, Kai ;
Zeng, Zheng-Yang ;
Hong, Wei ;
Li, Wen-Xin ;
Jia, Hui-Zhen ;
Liu, Yun ;
Zhuo, Ren-Xi ;
Zhang, Xian-Zheng .
SMALL, 2015, 11 (21) :2543-2554