RETRACTED: mRNP granules Assembly, function, and connections with disease (Retracted Article)

被引：338

作者：

Buchan, J. Ross ^{[1
]}

机构：

[1] Univ Arizona, Dept Mol & Cellular Biol, Tucson, AZ 85721 USA

来源：

RNA BIOLOGY | 2014年 / 11卷 / 08期

关键词：

stress granules; P-bodies; neuronal transport granules; germ granules; mRNA; translation; repression; decay; neurodegenerative disease; MESSENGER-RNA LOCALIZATION; EUKARYOTIC STRESS GRANULES; CELL-FREE FORMATION; P-BODIES; PROCESSING BODIES; TRANSLATION INITIATION; CHROMATOID BODY; RIBONUCLEOPROTEIN-PARTICLES; AGGREGATION-PRONE; PROTEIN GRANULES;

D O I：

10.4161/15476286.2014.972208

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Messenger ribonucleoprotein (mRNP) granules are dynamic, self-assembling structures that harbor non-translating mRNAs bound by various proteins that regulate mRNA translation, localization, and turnover. Their importance in gene expression regulation is far reaching, ranging from precise spatial-temporal control of mRNAs that drive developmental programs in oocytes and embryos, to similarly exquisite control of mRNAs in neurons that underpin synaptic plasticity, and thus, memory formation. Analysis of mRNP granules in their various contexts has revealed common themes of assembly, disassembly, and modes of mRNA regulation, yet new studies continue to reveal unexpected and important findings, such as links between aberrant mRNP granule assembly and neurodegenerative disease. Continued study of these enigmatic structures thus promises fascinating new insights into cellular function, and may also suggest novel therapeutic strategies in various disease states.

引用

页码：1019 / 1030

页数：12

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