Advances in liver organoids: model systems for liver disease

被引：12

作者：

Lee, Jaeseo ^{[1
]}

Mun, Seon Ju ^{[1
,2
]}

Shin, Yongbo ^{[1
,2
]}

Lee, Seonbhin ^{[1
,2
]}

Son, Myung Jin ^{[1
,2
]}

机构：

[1] Korea Res Inst Biosci & Biotechnol KRIBB, Stem Cell Convergence Res Ctr, 125 Gwahak Ro, Daejeon 34141, South Korea

[2] Korea Univ Sci & Technol UST, Dept Funct Genom, 217 Gajungro, Daejeon 34113, South Korea

来源：

ARCHIVES OF PHARMACAL RESEARCH | 2022年 / 45卷 / 06期

基金：

新加坡国家研究基金会;

关键词：

Liver; Organoids; Disease model; Drug screening; PLURIPOTENT STEM-CELLS; HEPATOCYTE-LIKE CELLS; FUNCTIONAL HUMAN LIVER; LONG-TERM EXPANSION; GENERATION; MATURATION; INFECTION; CULTURE;

D O I：

10.1007/s12272-022-01390-6

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Reliable in vitro models with human-derived cells that recapitulate in vivo-like physiologies are required for drug discovery and development to reduce the gap between the results of cell-based drug testing, animal testing, and human clinical trials. Liver organoid models have emerged as novel tools for hepatotoxicity evaluation, liver disease modeling, and drug screening. Liver organoids can be generated from biopsies of liver tissues or pluripotent stem cells and can be applied to various liver diseases, including metabolic associated fatty liver disease, infectious liver disease, genetic liver disease, and liver cancer. This review focuses on recent studies on organoids to model human liver diseases and discusses the advantages and limitations of current liver organoids for translational applications.

引用

页码：390 / 400

页数：11

共 82 条

[31] Long-Term Expansion of Functional Mouse and Human Hepatocytes as 3D Organoids [J].

Hu, Huili ;

Gehart, Helmuth ;

Artegiani, Benedetta ;

Lopez-Iglesias, Carmen ;

Dekkers, Florijn ;

Basak, Onur ;

van Es, Johan ;

Lopes, Susana M. Chuva de Sousa ;

Begthel, Harry ;

Korving, Jeroen ;

van den Born, Maaike ;

Zou, Chenhui ;

Quirk, Corrine ;

Chiriboga, Luis ;

Rice, Charles M. ;

Ma, Stephanie ;

Rios, Anne ;

Peters, Peter J. ;

de Jong, Ype P. ;

Clevers, Hans .

CELL, 2018, 175 (06) :1591-+

[32] Long-Term Culture of Genome-Stable Bipotent Stem Cells from Adult Human Liver [J].

Huch, Meritxell ;

Gehart, Helmuth ;

van Boxtel, Ruben ;

Hamer, Karien ;

Blokzijl, Francis ;

Verstegen, Monique M. A. ;

Ellis, Ewa ;

van Wenum, Martien ;

Fuchs, Sabine A. ;

de Ligt, Joep ;

van de Wetering, Marc ;

Sasaki, Nobuo ;

Boers, Susanne J. ;

Kemperman, Hans ;

de Jonge, Jeroen ;

Ijzermans, Jan N. M. ;

Nieuwenhuis, Edward E. S. ;

Hoekstra, Ruurdtje ;

Strom, Stephen ;

Vries, Robert R. G. ;

van der Laan, Luc J. W. ;

Cuppen, Edwin ;

Clevers, Hans .

CELL, 2015, 160 (1-2) :299-312

[33] Mitochondrial Respiratory Defect Causes Dysfunctional Lactate Turnover via AMP-activated Protein Kinase Activation in Human-induced Pluripotent Stem Cell-derived Hepatocytes [J].

Im, Ilkyun ;

Jang, Mi-jin ;

Park, Seung Ju ;

Lee, Sang-Hee ;

Choi, Jin-Ho ;

Yoo, Han-Wook ;

Kim, Seyun ;

Han, Yong-Mahn .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2015, 290 (49) :29493-29505

[34] Organ/body-on-a-chip based on microfluidic technology for drug discovery [J].

Kimura, Hiroshi ;

Sakai, Yasuyuki ;

Fujii, Teruo .

DRUG METABOLISM AND PHARMACOKINETICS, 2018, 33 (01) :43-48

[35] Modelling human hepato-biliary-pancreatic organogenesis from the foregut-midgut boundary [J].

Koike, Hiroyuki ;

Iwasawa, Kentaro ;

Ouchi, Rie ;

Maezawa, Mari ;

Giesbrecht, Kirsten ;

Saiki, Norikazu ;

Ferguson, Autumn ;

Kimura, Masaki ;

Thompson, Wendy L. ;

Wells, James M. ;

Zorn, Aaron M. ;

Takebe, Takanori .

NATURE, 2019, 574 (7776) :112-+

[36] An In Vitro Human Liver Model by iPSC-Derived Parenchymal and Non-parenchymal Cells [J].

Koui, Yuta ;

Kido, Taketomo ;

Ito, Toshimasa ;

Oyama, Hiroki ;

Chen, Shin-Wei ;

Katou, Yuki ;

Shirahige, Katsuhiko ;

Miyajima, Atsushi .

STEM CELL REPORTS, 2017, 9 (02) :490-498

[37] The potential and limitations of intrahepatic cholangiocyte organoids to study inborn errors of metabolism [J].

Lehmann, Vivian ;

Schene, Imre F. ;

Ardisasmita, Arif I. ;

Liv, Nalan ;

Veenendaal, Tineke ;

Klumperman, Judith ;

van der Doef, Hubert P. J. ;

Verkade, Henkjan J. ;

Verstegen, Monique M. A. ;

van der Laan, Luc J. W. ;

Jans, Judith J. M. ;

Verhoeven-Duif, Nanda M. ;

van Hasselt, Peter M. ;

Nieuwenhuis, Edward E. S. ;

Spee, Bart ;

Fuchs, Sabine A. .

JOURNAL OF INHERITED METABOLIC DISEASE, 2022, 45 (02) :353-365

[38] Human primary liver cancer organoids reveal intratumor and interpatient drug response heterogeneity [J].

Li, Ling ;

Knutsdottir, Hildur ;

Hui, Ken ;

Weiss, Matthew J. ;

He, Jin ;

Philosophe, Benjamin ;

Cameron, Andrew M. ;

Wolfgang, Christopher L. ;

Pawlik, Timothy M. ;

Ghiaur, Gabriel ;

Ewald, Andrew J. ;

Mezey, Esteban ;

Bader, Ljoel S. ;

Selaru, Florin M. .

JCI INSIGHT, 2019, 4 (02)

[39] Cancer-Associated Fibroblasts Provide a Stromal Niche for Liver Cancer Organoids That Confers Trophic Effects and Therapy Resistance [J].

Liu, Jiaye ;

Li, Pengfei ;

Wang, Ling ;

Li, Meng ;

Ge, Zhouhong ;

Noordam, Lisanne ;

Lieshout, Ruby ;

Verstegen, Monique M. A. ;

Ma, Buyun ;

Su, Junhong ;

Yang, Qin ;

Zhang, Ruyi ;

Zhou, Guoying ;

Carrascosa, Lucia Campos ;

Sprengers, Dave ;

IJzermans, Jan N. M. ;

Smits, Ron ;

Kwekkeboom, Jaap ;

van der Laan, Luc J. W. ;

Peppelenbosch, Maikel P. ;

Pan, Qiuwei ;

Cao, Wanlu .

CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY, 2021, 11 (02) :407-431

[40] The Interplay between Alcoholic Liver Disease, Obesity, and the Metabolic Syndrome [J].

Malnick, Stephen ;

Maor, Yaakov .

VISCERAL MEDICINE, 2020, 36 (03) :198-205

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