Advances in liver organoids: model systems for liver disease

被引：12

作者：

Lee, Jaeseo ^{[1
]}

Mun, Seon Ju ^{[1
,2
]}

Shin, Yongbo ^{[1
,2
]}

Lee, Seonbhin ^{[1
,2
]}

Son, Myung Jin ^{[1
,2
]}

机构：

[1] Korea Res Inst Biosci & Biotechnol KRIBB, Stem Cell Convergence Res Ctr, 125 Gwahak Ro, Daejeon 34141, South Korea

[2] Korea Univ Sci & Technol UST, Dept Funct Genom, 217 Gajungro, Daejeon 34113, South Korea

来源：

ARCHIVES OF PHARMACAL RESEARCH | 2022年 / 45卷 / 06期

基金：

新加坡国家研究基金会;

关键词：

Liver; Organoids; Disease model; Drug screening; PLURIPOTENT STEM-CELLS; HEPATOCYTE-LIKE CELLS; FUNCTIONAL HUMAN LIVER; LONG-TERM EXPANSION; GENERATION; MATURATION; INFECTION; CULTURE;

D O I：

10.1007/s12272-022-01390-6

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Reliable in vitro models with human-derived cells that recapitulate in vivo-like physiologies are required for drug discovery and development to reduce the gap between the results of cell-based drug testing, animal testing, and human clinical trials. Liver organoid models have emerged as novel tools for hepatotoxicity evaluation, liver disease modeling, and drug screening. Liver organoids can be generated from biopsies of liver tissues or pluripotent stem cells and can be applied to various liver diseases, including metabolic associated fatty liver disease, infectious liver disease, genetic liver disease, and liver cancer. This review focuses on recent studies on organoids to model human liver diseases and discusses the advantages and limitations of current liver organoids for translational applications.

引用

页码：390 / 400

页数：11

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