Carane amino alcohols as organocatalysts in asymmetric aldol reaction of isatin with acetone

被引：13

作者：

Banina, O. A. ^{[1
]}

Sudarikov, D. V. ^{[1
]}

Nigmatov, A. G. ^{[2
]}

Frolova, L. L. ^{[1
]}

Slepukhin, P. A. ^{[3
]}

Zlotin, S. G. ^{[2
]}

Kutchin, A. V. ^{[1
]}

机构：

[1] Russian Acad Sci, Inst Chem, Ural Branch, Komi Sci Ctr, 48 Ul Pervomaiskaya, Syktyvkar 167000, Russia

[2] Russian Acad Sci, ND Zelinsky Inst Organ Chem, 47 Leninsky Prosp, Moscow 119991, Russia

[3] Russian Acad Sci, IYa Postovsky Inst Organ Synth, Ural Branch, 22 Ul S Kovalevskoi, Ekaterinburg 620219, Russia

来源：

RUSSIAN CHEMICAL BULLETIN | 2017年 / 66卷 / 02期

基金：

俄罗斯基础研究基金会;

关键词：

amino alcohols; 3-carene; asymmetric synthesis; organocatalysts; aldol reaction; isatin; ENANTIOSELECTIVE ADDITION; DIETHYLZINC; ALDEHYDES; (+)-3-CARENE; CATALYSTS;

D O I：

10.1007/s11172-017-1730-y

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Carane-derived beta-amino alcohols with amino and hydroxy groups at positions 3 and 4 differing in their mutual arrangement and configuration were synthesized. Their application as organocatalysts in the asymmetric aldol reaction of isatin with acetone allowed one to obtain adducts with up to 84% enantiomeric excess.

引用

页码：293 / 296

页数：4

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