How and when should we monitor chimerism after allogeneic stem cell transplantation?

被引：146
|
作者：
Bader, P
Niethammer, D
Willasch, A
Kreyenberg, H
Klingebiel, T
机构：
[1] Univ Childrens Hosp, Dept Pediat Hematol & Oncol, D-72070 Tubingen, Germany
[2] Univ Childrens Hosp, Frankfurt, Germany
来源：
BONE MARROW TRANSPLANTATION | 2005年 / 35卷 / 02期
关键词：
chimerism; allogeneic stem cell transplantation;
D O I：
10.1038/sj.bmt.1704715
中图分类号：
Q6 [生物物理学];
学科分类号：
071011 ;
摘要：
Chimerism analysis has become an important tool for the peri-transplant surveillance of engraftment. It offers the possibility to realize impending graft rejection and can serve as an indicator for the recurrence of the underlying malignant or nonmalignant disease. Most recently, these investigations have become the basis for treatment intervention, for example, to avoid graft rejection, to maintain engraftment and to treat imminent relapse by pre-emptive immunotherapy. This invited review focuses on the clinical implications of characterization of hematopoietic chimerism in stem cell transplantation.
引用
收藏
页码：107 / 119
页数：13
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