Habitual sleep duration is associated with BMI and macronutrient intake and may be modified by CLOCK genetic variants

被引：94

作者：

Dashti, Hassan S. ^{[1
]}

Follis, Jack L. ^{[4
]}

Smith, Caren E. ^{[1
]}

Tanaka, Toshiko ^{[5
]}

Cade, Brian E. ^{[7
,10
]}

Gottlieb, Daniel J. ^{[7
,10
,13
]}

Hruby, Adela ^{[14
]}

Jacques, Paul F. ^{[2
]}

Lamon-Fava, Stefania ^{[3
]}

Richardson, Kris ^{[1
]}

Saxena, Richa ^{[7
,15
,16
,17
]}

Scheer, Frank A. J. L. ^{[7
,10
]}

Kovanen, Leena ^{[18
,19
]}

Bartz, Traci M. ^{[22
,23
,24
]}

Perala, Mia-Maria ^{[20
]}

Jonsson, Anna ^{[29
]}

Frazier-Wood, Alexis C. ^{[31
]}

Kalafati, Ioanna-Panagiota ^{[32
]}

Mikkila, Vera ^{[33
]}

Partonen, Timo ^{[18
,19
]}

Lemaitre, Rozenn N. ^{[22
,23
]}

Lahti, Jari ^{[34
,36
]}

Hernandez, Dena G. ^{[6
]}

Toft, Ulla ^{[37
]}

Johnson, W. Craig ^{[24
]}

Kanoni, Stavroula ^{[39
]}

Raitakari, Olli T. ^{[40
,41
]}

Perola, Markus ^{[20
]}

Psaty, Bruce M. ^{[22
,23
,25
,45
]}

Ferrucci, Luigi ^{[5
]}

Grarup, Niels ^{[29
]}

Highland, Heather M. ^{[46
]}

Rallidis, Loukianos ^{[47
]}

Kahonen, Mika ^{[48
,49
]}

Havulinna, Aki S. ^{[20
]}

Siscovick, David S. ^{[50
]}

Raikkonen, Katri ^{[34
]}

Jorgensen, Torben ^{[37
]}

Rotter, Jerome I. ^{[51
]}

Deloukas, Panos ^{[39
,52
]}

Viikari, Jorma S. A. ^{[42
,43
,44
]}

Mozaffarian, Dariush ^{[8
,9
,11
,12
,14
]}

Linneberg, Allan ^{[30
,38
]}

Seppala, Ilkka ^{[53
]}

Hansen, Torben ^{[29
]}

Salomaa, Veikko ^{[20
]}

Gharib, Sina A. ^{[23
,26
,27
,28
]}

Eriksson, Johan G. ^{[20
,35
,36
,54
,55
]}

Bandinelli, Stefania ^{[56
]}

Pedersen, Oluf ^{[29
]}

机构：

[1] Tufts Univ, Jean Mayer USDA, Human Nutr Res Ctr Aging, Nutr & Genom Lab, Boston, MA 02111 USA

[2] Tufts Univ, Jean Mayer USDA, Human Nutr Res Ctr Aging, Nutr Epidemiol Lab, Boston, MA 02111 USA

[3] Tufts Univ, Jean Mayer USDA, Human Nutr Res Ctr Aging, Cardiovasc Nutr Lab, Boston, MA 02111 USA

[4] Univ St Thomas, Dept Math Comp Sci & Cooperat Engn, Houston, TX 77006 USA

[5] NIH, Translat Gerontol Branch, Baltimore, MD USA

[6] NIH, Neurogenet Lab, Baltimore, MD USA

[7] Brigham & Womens Hosp, Div Sleep & Circadian Disorders, Boston, MA 02115 USA

[8] Brigham & Womens Hosp, Div Cardiovasc Med, Boston, MA 02115 USA

[9] Brigham & Womens Hosp, Channing Div Network Med, Boston, MA 02115 USA

[10] Harvard Univ, Sch Med, Div Sleep Med, Boston, MA USA

[11] Harvard Univ, Sch Med, Div Cardiovasc Med, Boston, MA USA

[12] Harvard Univ, Sch Med, Charming Div Network Med, Boston, MA USA

[13] VA Boston Healthcare Syst, Sleep Disorders Ctr, Boston, MA USA

[14] Harvard Sch Publ Hlth, Dept Nutr, Boston, MA 02115 USA

[15] Massachusetts Gen Hosp, Ctr Human Genet Res, Boston, MA 02114 USA

[16] Massachusetts Gen Hosp, Dept Anesthesia Crit Care & Pain Med, Boston, MA 02114 USA

[17] Harvard Sch Med, Boston, MA USA

[18] Natl Inst Hlth & Welf, Dept Mental Hlth, Helsinki, Finland

[19] Natl Inst Hlth & Welf, Dept Substance Abuse Serv, Helsinki, Finland

[20] Natl Inst Hlth & Welf, Dept Chron Dis Prevent, Helsinki, Finland

[21] Natl Inst Hlth & Welf, Helsinki, Finland

[22] Univ Washington, Cardiovasc Hlth Res Unit, Seattle, WA 98195 USA

[23] Univ Washington, Dept Med, Seattle, WA 98195 USA

[24] Univ Washington, Dept Biostat, Seattle, WA 98195 USA

[25] Univ Washington, Dept Epidemiol & Hlth Serv, Seattle, WA 98195 USA

[26] Univ Washington, Dept Computat Med, Seattle, WA 98195 USA

[27] Univ Washington, Ctr Lung Biol, Seattle, WA 98195 USA

[28] Univ Washington, Univ Washington Med Sleep Ctr, Seattle, WA USA

[29] Univ Copenhagen, Novo Nordisk Fdn, Ctr Basic Metab Res, Copenhagen, Denmark

[30] Univ Copenhagen, Dept Clin Med, Fac Hlth & Med Sci, Copenhagen, Denmark

[31] Baylor Coll Med, USDA ARS, Childrens Nutr Res Ctr, Dept Pediat, Houston, TX 77030 USA

[32] Harokopio Univ, Dept Nutr & Dietet, Athens, Greece

[33] Univ Helsinki, Dept Food & Environm Sci, Div Nutr, Helsinki, Finland

[34] Univ Helsinki, Inst Behav Sci, Helsinki, Finland

[35] Univ Helsinki, Dept Gen Practice & Primary Hlth Care, Helsinki, Finland

[36] Folkhalsan Res Ctr, Helsinki, Finland

[37] Glostrup Univ Hosp, Res Ctr Prevent & Hlth, Glostrup, Denmark

[38] Glostrup Univ Hosp, Dept Clin Expt Res, Glostrup, Denmark

[39] William Harvey Res Inst, London, England

[40] Univ Turku, Res Ctr Appl & Prevent Cardiovasc Med, Turku, Finland

[41] Univ Turku, Dept Clin Physiol & Nucl Med, Turku, Finland

[42] Univ Turku, Dept Med, Turku, Finland

[43] Univ Turku, Div Med, Turku, Finland

[44] Turku Univ Hosp, Turku, Finland

[45] Grp Hlth Res Inst, Grp Hlth, Seattle, WA USA

[46] Univ Texas Hlth Sci Ctr Houston, Ctr Human Genet, Univ Texas Grad Sch Biomed Sci Houston, Sch Publ Hlth, Houston, TX 77030 USA

[47] Univ Gen Hosp, Dept Cardiol 2, Athens, Greece

[48] Tampere Univ Hosp, Dept Clin Physiol, Tampere, Finland

[49] Univ Tampere, FIN-33101 Tampere, Finland

[50] New York Acad Med, New York, NY USA

来源：

AMERICAN JOURNAL OF CLINICAL NUTRITION | 2015年 / 101卷 / 01期

基金：

芬兰科学院;

关键词：

CLOCK; circadian rhythm; dietary intake; gene-environment interaction; sleep duration; FOOD FREQUENCY QUESTIONNAIRE; ENERGY-EXPENDITURE; METAANALYSIS; SEX; CURTAILMENT; VALIDITY; OBESITY; HUNGER; AGE;

D O I：

10.3945/ajcn.114.095026

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

Background: Short sleep duration has been associated with greater risks of obesity, hypertension, diabetes, and cardiovascular disease. Also, common genetic variants in the human Circadian Locomotor Output Cycles Kaput (CLOCK) show associations with ghrelin and total energy intake. Objectives: We examined associations between habitual sleep duration, body mass index (BM), and macronutrient intake and assessed whether CLOCK variants modify these associations. Design: We conducted inverse-variance weighted, fixed-effect meta-analyses of results of adjusted associations of sleep duration and BMI and macronutrient intake as percentages of total energy as well as interactions with CLOCK variants from 9 cohort studies including up to 14,906 participants of European descent from the Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium. Results: We observed a significant association between sleep duration and lower BMI (beta +/- SE = 0.16 +/- 0.04, P < 0.0001) in the overall sample; however, associations between sleep duration and relative macronutrient intake were evident in age- and sex-stratified analyses only. We observed a significant association between sleep duration and lower saturated fatty acid intake in younger (aged 20-64 y) adults (men: 0.11 +/- 0.06%, P = 0.03; women: 0.10 +/- 0.05%, P = 0.04) and with lower carbohydrate (-0.31 0.12%, P < 0.01), higher total fat (0.18 +/- 0.09%, P = 0.05), and higher PUFA (0.05 +/- 0.02%, P = 0.02) intakes in older (aged 65-80 y) women. In addition, the following 2 nominally significant interactions were observed: between sleep duration and rs12649507 on PUFA intake and between sleep duration and rs6858749 on protein intake. Conclusions: Our results indicate that longer habitual sleep duration is associated with lower BMI and age- and sex-specific favorable dietary behaviors. Differences in the relative intake of specific macronutrients associated with short sleep duration could, at least in part, explain previously reported associations between short sleep duration and chronic metabolic abnormalities. In addition, the influence of obesity-associated CLOCK variants on the association between sleep duration and macronutrient intake suggests that longer habitual sleep duration could ameliorate the genetic predisposition to obesity via a favorable dietary profile.

引用

页码：135 / 143

页数：9

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