Beyond C2 and C3: Transition-Metal-Catalyzed C-H Functionalization of Indole

被引：377

作者：

Leitch, Jamie A. ^{[1
]}

Bhonoah, Yunas ^{[2
]}

Frost, Christopher G. ^{[1
]}

机构：

[1] Univ Bath, Dept Chem, Bath BA2 7AY, Somerset, England

[2] Syngenta, Jealotts Hill Int Res Ctr, Bracknell RG42 6EY, Berks, England

来源：

ACS CATALYSIS | 2017年 / 7卷 / 09期

关键词：

indole; C-H functionalization; regioselectivity; heteroaromatics; homogeneous catalysis; DIRECTING GROUP; BOND FUNCTIONALIZATIONS; 2,3-DISUBSTITUTED INDOLES; REGIOSELECTIVE SYNTHESIS; ROOM-TEMPERATURE; NATURAL-PRODUCTS; ACTIVATION; ARYLATION; ALKYLATION; ARENES;

D O I：

10.1021/acscatal.7b01785

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

The indole scaffold will continue to play a vital part in the future of drug discovery and agrochemical development. Because of this, the necessity for elegant techniques to enable selective C-H functionalization is vast. Early developments have led to primarily C2 and C3 functionalization because of the inherent reactivity of the pyrrole ring. Despite this, elegant methods have been developed to enable selective C-H functionalization on the benzenoid moiety at C4, C5, C6, and C7. This review focuses on the contributions made in benzenoid C-H functionalization of indoles and other related heteroaromatics such as carbazoles.

引用

页码：5618 / 5627

页数：10

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