Is a Human CD8 T-Cell Vaccine Possible, and if So, What Would It Take? Could a CD8+ T-Cell Vaccine Prevent Persistent HIV Infection?

被引：9

作者：

McMichael, Andrew J. ^{[1
]}

机构：

[1] Univ Oxford, Nuffield Dept Med, Oxford OX3 7FZ, England

来源：

COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY | 2018年 / 10卷 / 09期

基金：

英国医学研究理事会; 美国国家卫生研究院;

关键词：

MAJOR HISTOCOMPATIBILITY COMPLEX; VIRUS-INFECTION; RHESUS-MONKEYS; EFFICACY TRIAL; PROTECTION; INFLUENZA; RESPONSES; CYTOMEGALOVIRUS; CHALLENGE; IMMUNITY;

D O I：

10.1101/cshperspect.a029124

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Vaccines that stimulate CD8(+) T cells could clear early virus infection or control ongoing infection and prevent disease. This could be valuable to combat human immunodeficiency virus type 1 (HIV-1) where it has not yet been possible to generate broadly reacting neutralizing antibodies with a vaccine. However, HIV-1 vaccines aimed at stimulating CD8(+) T cells have had no success. In contrast, a cytomegalovirus vectored simian immunodeficiency virus (SIV) vaccine enabled clearance of early SIV infection. This may open the door to the design of an effective HIV vaccine

引用

页数：9

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