The TRPA1 Channel in the Cardiovascular System: Promising Features and Challenges

被引：35
|
作者：
Wang, Zhen [1 ,2 ,3 ]
Ye, Di [1 ,2 ,3 ]
Ye, Jing [1 ,2 ,3 ]
Wang, Menglong [1 ,2 ,3 ]
Liu, Jianfang [1 ,2 ,3 ]
Jiang, Huimin [1 ,2 ,3 ]
Xu, Yao [1 ,2 ,3 ]
Zhang, Jishou [1 ,2 ,3 ]
Chen, Jiangbin [1 ,2 ,3 ]
Wan, Jun [1 ,2 ,3 ]
机构：
[1] Wuhan Univ, Renmin Hosp, Dept Cardiol, Wuhan, Hubei, Peoples R China
[2] Wuhan Univ, Cardiovasc Res Inst, Wuhan, Hubei, Peoples R China
[3] Hubei Key Lab Cardiol, Wuhan, Hubei, Peoples R China
来源：
FRONTIERS IN PHARMACOLOGY | 2019年 / 10卷
关键词：
TRPA1; channel; atherosclerosis; heart failure; myocardial ischemia-reperfusion injury; myocardial fibrosis; arrhythmia; vasodilation; hypertension; AUTONOMIC NERVOUS-SYSTEM; RECEPTOR POTENTIAL A1; ION-CHANNEL; NEUROGENIC INFLAMMATION; MYOCARDIAL-ISCHEMIA; HEART-FAILURE; AIR-POLLUTION; CA2+ SIGNALS; RISK-FACTORS; ACTIVATION;
D O I：
10.3389/fphar.2019.01253
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The transient receptor potential ankyrin 1 (TRPA1) channel is a calcium-permeable nonselective cation channel in the plasma membrane that belongs to the transient receptor potential (TRP) channel superfamily. Recent studies have suggested that the TRPA1 channel plays an essential role in the development and progression of several cardiovascular conditions, such as atherosclerosis, heart failure, myocardial ischemia-reperfusion injury, myocardial fibrosis, arrhythmia, vasodilation, and hypertension. Activation of the TRPA1 channel has a protective effect against the development of atherosclerosis. Furthermore, TRPA1 channel activation elicits peripheral vasodilation and induces a biphasic blood pressure response. However, loss of channel expression or blockade of its activation suppressed heart failure, myocardial ischemia-reperfusion injury, myocardial fibrosis, and arrhythmia. In this paper, we review recent research progress on the TRPA1 channel and discuss its potential role in the cardiovascular system.
引用
收藏
页数：11
相关论文
共 50 条
  • [31] The 'headache tree' via umbellulone and TRPA1 activates the trigeminovascular system
    Nassini, Romina
    Materazzi, Serena
    Vriens, Joris
    Prenen, Jean
    Benemei, Silvia
    De Siena, Gaetano
    la Marca, Giancarlo
    Andre, Eunice
    Preti, Delia
    Avonto, Cristina
    Sadofsky, Laura
    Di Marzo, Vincenzo
    De Petrocellis, Luciano
    Dussor, Greg
    Porreca, Frank
    Taglialatela-Scafati, Orazio
    Appendino, Giovanni
    Nilius, Bernd
    Geppetti, Pierangelo
    BRAIN, 2012, 135 : 376 - 390
  • [32] Transient Receptor Potential Ankyrin 1 (TRPA1) Channel and Neurogenic Inflammation in Pathogenesis of Asthma
    Yang, Hang
    Li, ShuZhuang
    MEDICAL SCIENCE MONITOR, 2016, 22 : 2917 - 2923
  • [33] TRPA1 receptor is upregulated in human oral lichen planus
    Kun, J.
    Perkecz, A.
    Knie, L.
    Setalo, G., Jr.
    Tornoczki, T.
    Pinter, E.
    Ban, A.
    ORAL DISEASES, 2017, 23 (02) : 189 - 198
  • [34] Development of novel azabenzofuran TRPA1 antagonists as in vivo tools
    Copeland, Katrina W.
    Boezio, Alessandro A.
    Cheung, Eugene
    Lee, Josie
    Olivieri, Philip
    Schenkel, Laurie B.
    Wan, Qian
    Wang, Weiya
    Wells, Mary C.
    Youngblood, Beth
    Gavva, Narender R.
    Lehto, Sonya G.
    Geuns-Meyer, Stephanie
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2014, 24 (15) : 3464 - 3468
  • [35] A Mechanism for the Treatment of Cardiovascular and Renal Disease: TRPV1 and TRPA1
    Gao, Lu
    Wang, Qi
    Li, Min-yi
    Zhang, Meng-Meng
    Wang, Bin
    Dong, Tai-Wei
    Wei, Pei-Feng
    Li, Min
    JOURNAL OF CARDIOVASCULAR PHARMACOLOGY, 2024, 84 (01) : 10 - 17
  • [36] Multimerization of Homo sapiens TRPA1 ion channel cytoplasmic domains
    Martinez, Gilbert Q.
    Gordon, Sharona E.
    PLOS ONE, 2019, 14 (02):
  • [37] The TRPA1 channel and oral hypoglycemic agents Is there complicity in β cell exhaustion?
    Manlio Diaz-Garcia, Carlos
    CHANNELS, 2013, 7 (06) : 420 - 422
  • [38] TRPA1 and other TRP channels in migraine
    Benemei, Silvia
    De Cesaris, Francesco
    Fusi, Camilla
    Rossi, Eleonora
    Lupi, Chiara
    Geppetti, Pierangelo
    JOURNAL OF HEADACHE AND PAIN, 2013, 14 : 71
  • [39] Structural Insights into Electrophile Irritant Sensing by the Human TRPA1 Channel
    Suo, Yang
    Wang, Zilong
    Zubcevic, Lejla
    Hsu, Allen L.
    He, Qianru
    Borgnia, Mario J.
    Ji, Ru-Rong
    Lee, Seok-Yong
    NEURON, 2020, 105 (05) : 882 - +
  • [40] The transient receptor potential channel TRPA1: from gene to pathophysiology
    Nilius, Bernd
    Appendino, Giovanni
    Owsianik, Grzegorz
    PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY, 2012, 464 (05): : 425 - 458
12345