The TRPA1 Channel in the Cardiovascular System: Promising Features and Challenges

被引：35

作者：

Wang, Zhen ^{[1
,2
,3
]}

Ye, Di ^{[1
,2
,3
]}

Ye, Jing ^{[1
,2
,3
]}

Wang, Menglong ^{[1
,2
,3
]}

Liu, Jianfang ^{[1
,2
,3
]}

Jiang, Huimin ^{[1
,2
,3
]}

Xu, Yao ^{[1
,2
,3
]}

Zhang, Jishou ^{[1
,2
,3
]}

Chen, Jiangbin ^{[1
,2
,3
]}

Wan, Jun ^{[1
,2
,3
]}

机构：

[1] Wuhan Univ, Renmin Hosp, Dept Cardiol, Wuhan, Hubei, Peoples R China

[2] Wuhan Univ, Cardiovasc Res Inst, Wuhan, Hubei, Peoples R China

[3] Hubei Key Lab Cardiol, Wuhan, Hubei, Peoples R China

来源：

FRONTIERS IN PHARMACOLOGY | 2019年 / 10卷

关键词：

TRPA1; channel; atherosclerosis; heart failure; myocardial ischemia-reperfusion injury; myocardial fibrosis; arrhythmia; vasodilation; hypertension; AUTONOMIC NERVOUS-SYSTEM; RECEPTOR POTENTIAL A1; ION-CHANNEL; NEUROGENIC INFLAMMATION; MYOCARDIAL-ISCHEMIA; HEART-FAILURE; AIR-POLLUTION; CA2+ SIGNALS; RISK-FACTORS; ACTIVATION;

D O I：

10.3389/fphar.2019.01253

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The transient receptor potential ankyrin 1 (TRPA1) channel is a calcium-permeable nonselective cation channel in the plasma membrane that belongs to the transient receptor potential (TRP) channel superfamily. Recent studies have suggested that the TRPA1 channel plays an essential role in the development and progression of several cardiovascular conditions, such as atherosclerosis, heart failure, myocardial ischemia-reperfusion injury, myocardial fibrosis, arrhythmia, vasodilation, and hypertension. Activation of the TRPA1 channel has a protective effect against the development of atherosclerosis. Furthermore, TRPA1 channel activation elicits peripheral vasodilation and induces a biphasic blood pressure response. However, loss of channel expression or blockade of its activation suppressed heart failure, myocardial ischemia-reperfusion injury, myocardial fibrosis, and arrhythmia. In this paper, we review recent research progress on the TRPA1 channel and discuss its potential role in the cardiovascular system.

引用

页数：11

共 50 条

[21] A TRPA1 channel that senses thermal stimulus and irritating chemicals in Helicoverpa armigera
Wei, J. J.
Fu, T.
Yang, T.
Liu, Y.
Wang, G. R.
INSECT MOLECULAR BIOLOGY, 2015, 24 (04) : 412 - 421
[22] TRPA1 and thermosensitivity
Tominaga, Makoto
Iwata, Moe
JOURNAL OF PHYSIOLOGICAL SCIENCES, 2025, 75 (01)
[23] The TRPA1 Channel Amplifies the Oxidative Stress Signal in Melanoma
De Logu, Francesco
Souza Monteiro de Araujo, Daniel
Ugolini, Filippo
Iannone, Luigi Francesco
Vannucchi, Margherita
Portelli, Francesca
Landini, Lorenzo
Titiz, Mustafa
De Giorgi, Vincenzo
Geppetti, Pierangelo
Massi, Daniela
Nassini, Romina
CELLS, 2021, 10 (11)
[24] The conducting state of TRPA1 modulates channel lateral mobility
Sampieri, Alicia
Padilla-Flores, Teresa
Thawani, Aditya R.
Lam, Pui-Ying
Fuchter, Matthew J.
Peterson, Randall
Vaca, Luis
CELL CALCIUM, 2023, 116
[25] Irritating channels: the case of TRPA1
Nilius, Bernd
Prenen, Jean
Owsianik, Grzegorz
JOURNAL OF PHYSIOLOGY-LONDON, 2011, 589 (07): : 1543 - 1549
[26] Research Progress on TRPA1 in Diseases
Li, Jiajing
Zhang, Hongfei
Du, Qian
Gu, Junyu
Wu, Jiangbo
Liu, Qi
Li, Zhuo
Zhang, Ting
Xu, Jingyu
Xie, Rui
JOURNAL OF MEMBRANE BIOLOGY, 2023, 256 (4-6) : 301 - 316
[27] Analogues of perillaketone as highly potent agonists of TRPA1 channel
Bassoli, A.
Borgonovo, G.
Morini, G.
De Petrocellis, L.
Moriello, A. Schiano
Di Marzo, V.
FOOD CHEMISTRY, 2013, 141 (03) : 2044 - 2051
[28] Identification of a splice variant of mouse TRPA1 that regulates TRPA1 activity
Zhou, Yiming
Suzuki, Yoshiro
Uchida, Kunitoshi
Tominaga, Makoto
NATURE COMMUNICATIONS, 2013, 4
[29] The Dynamic TRPA1 Channel: A Suitable Pharmacological Pain Target?
Garrison, Sheldon R.
Stucky, Cheryl L.
CURRENT PHARMACEUTICAL BIOTECHNOLOGY, 2011, 12 (10) : 1689 - 1697
[30] Structure of the TRPA1 ion channel suggests regulatory mechanisms
Paulsen, Candice E.
Armache, Jean-Paul
Gao, Yuan
Cheng, Yifan
Julius, David
NATURE, 2015, 520 (7548) : 511 - +

← 1 2 3 4 5 →