No longer a nuisance: long non-coding RNAs join CENP-A in epigenetic centromere regulation

被引：33

作者：

Rosic, Silvana ^{[1
]}

Erhardt, Sylvia ^{[2
]}

机构：

[1] Univ London Imperial Coll Sci Technol & Med, Ctr Clin Sci, MRC, London, England

[2] Heidelberg Univ, DKFZ ZMBH Alliance & CellNetworks Excellence Clus, ZMBH, Neuenheimer Feld 282, D-69120 Heidelberg, Germany

来源：

CELLULAR AND MOLECULAR LIFE SCIENCES | 2016年 / 73卷 / 07期

关键词：

Centromere; Kinetochore; Mitosis; Long non-coding RNA; Epigenetics; Transcription; EMBRYONIC STEM-CELLS; FISSION YEAST; CHROMOSOME SEGREGATION; DROSOPHILA CENTROMERE; KINETOCHORE FORMATION; HUMAN NEOCENTROMERE; POLYMERASE-II; PROTEIN-A; TRANSCRIPTION; CHROMATIN;

D O I：

10.1007/s00018-015-2124-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Centromeres represent the basis for kinetochore formation, and are essential for proper chromosome segregation during mitosis. Despite these essential roles, centromeres are not defined by specific DNA sequences, but by epigenetic means. The histone variant CENP-A controls centromere identity epigenetically and is essential for recruiting kinetochore components that attach the chromosomes to the mitotic spindle during mitosis. Recently, a new player in centromere regulation has emerged: long non-coding RNAs transcribed from repetitive regions of centromeric DNA function in regulating centromeres epigenetically. This review summarizes recent findings on the essential roles that transcription, pericentromeric transcripts, and centromere-derived RNAs play in centromere biology.

引用

页码：1387 / 1398

页数：12

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