Review of Small Synthetic Molecules Targeting HBV Capsid Assembly

被引：9

作者：

Liu, Na ^{[1
]}

Zhao, Fabao ^{[1
]}

Zhan, Peng ^{[1
]}

Liu, Xinyong ^{[1
]}

机构：

[1] Shandong Univ, Sch Pharmaceut Sci, Key Lab Chem Biol, Dept Med Chem,Minist Educ, 44 West Culture Rd, Jinan, Shandong, Peoples R China

来源：

MEDICINAL CHEMISTRY | 2015年 / 11卷 / 08期

基金：

中国国家自然科学基金; 高等学校博士学科点专项科研基金;

关键词：

HBV; inhibitors; non-nucleosides; small synthetic molecules; capsid assembly; HEPATITIS-B-VIRUS; PHENYLPROPENAMIDE DERIVATIVES; IN-VITRO; REPLICATION; CORE; INHIBITION; COMPOUND; PROTEIN; GLS4; NUCLEOCAPSIDS;

D O I：

10.2174/157340641108151029111243

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Currently, the treatment for HBV infection suffers from adverse side effects and drug resistance. The dramatic development of new HBV inhibitors is focused on discovering diverse non-nucleoside compounds with either novel structures or new mechanisms of action. Capsid assembly is crucial to the completion of the viral life cycle, which makes it an attractive target for antivirus discovery. Inhibitors that block the formation of the HBV capsid have been developed, and several candidates have been proposed. In this review, we focus on the recent advances in several distinct classes of synthetic small molecular non-nucleosides targeting at the capsid assembly.

引用

页码：710 / 716

页数：7

共 43 条

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