Prevalence of Periodontitis in Patients with Established Rheumatoid Arthritis: A Swedish Population Based Case-Control Study

被引:70
作者
Eriksson, Kaja [1 ]
Nise, Lena [2 ]
Kats, Anna [1 ]
Luttropp, Elin [1 ]
Catrina, Anca Irinel [3 ]
Askling, Johan [3 ]
Jansson, Leif [1 ,4 ]
Alfredsson, Lars [2 ,5 ]
Klareskog, Lars [3 ]
Lundberg, Karin [3 ]
Yucel-Lindberg, Tulay [1 ]
机构
[1] Karolinska Inst, Div Periodontol, Dept Dent Med, Huddinge, Sweden
[2] Karolinska Inst, Inst Environm Med, Solna, Sweden
[3] Karolinska Univ Hosp, Rheumatol Unit, Dept Med, Stockholm, Sweden
[4] Stockholm Cty Council, Dept Periodontol, Eastmaninst, Stockholm, Sweden
[5] Stockholm Cty Council, Ctr Environm & Occupat Med, Stockholm, Sweden
基金
瑞典研究理事会;
关键词
GINGIVAL CREVICULAR FLUID; CITRULLINATED PROTEINS; ALPHA-ENOLASE; TOOTH LOSS; DISEASE; RISK; ASSOCIATION; AUTOIMMUNITY; PATHOGENESIS; INTERLEUKIN-1;
D O I
10.1371/journal.pone.0155956
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Introduction The possible hypothesis of a link between periodontitis and rheumatoid arthritis (RA), specifically anti-citrullinated protein antibody (ACPA) positive RA, prompted us to investigate the prevalence of periodontitis in the Swedish Epidemiological Investigation of RA (EIRA), a well-characterised population-based RA case-control cohort. Methods Periodontal status of 2,740 RA cases and 3,942 matched controls was retrieved through linking EIRA with the National Dental Health Registry (DHR), where dental diagnostic-and treatment codes on the adult Swedish population have been registered. Dental records from 100 cases and controls were reviewed to validate the periodontal diagnostic codes in DHR. Results The reviewed dental records confirmed 90% of the periodontitis diagnoses in DHR among RA cases, and 88% among controls. We found the positive predictive value of periodontitis diagnoses in the DHR to be 89% (95% CI 78 to 95%) with a sensitivity of 77% (95% CI: 65 to 86%). In total, 86% of EIRA participants were identified in DHR. The risk for periodontitis increased by age and current smoking status in both cases as well as controls. No significant differences in prevalence of periodontal disease in terms of gingivitis, periodontitis, peri-implantitis or increased risk for periodontitis or peri-implantitis were observed between RA cases and controls. In addition, there was no difference on the basis of seropositivity, ACPA or rheumatoid factor (RF), among patients with RA. Conclusions Our data verify that smoking and ageing are risk factors for periodontitis, both in RA and controls. We found no evidence of an increased prevalence of periodontitis in patients with established RA compared to healthy controls, and no differences based on ACPA or RF status among RA subjects.
引用
收藏
页数:16
相关论文
共 64 条
[1]   Relationship between Periodontitis and Rheumatoid Arthritis: Review of the Literature [J].
Adriano Arajo, Vilana Maria ;
Melo, Iracema Matos ;
Lima, Vilma .
MEDIATORS OF INFLAMMATION, 2015, 2015
[2]  
[Anonymous], 2005, J PERIODONTOL, V76, P1406, DOI 10.1902/jop.2005.76.8.1406
[3]   A Prospective Study of Periodontal Disease and Risk of Rheumatoid Arthritis [J].
Arkema, Elizabeth V. ;
Karlson, Elizabeth W. ;
Costenbader, Karen H. .
JOURNAL OF RHEUMATOLOGY, 2010, 37 (09) :1800-1804
[4]  
Armitage G C, 1999, Ann Periodontol, V4, P1, DOI 10.1902/annals.1999.4.1.1
[5]   THE AMERICAN-RHEUMATISM-ASSOCIATION 1987 REVISED CRITERIA FOR THE CLASSIFICATION OF RHEUMATOID-ARTHRITIS [J].
ARNETT, FC ;
EDWORTHY, SM ;
BLOCH, DA ;
MCSHANE, DJ ;
FRIES, JF ;
COOPER, NS ;
HEALEY, LA ;
KAPLAN, SR ;
LIANG, MH ;
LUTHRA, HS ;
MEDSGER, TA ;
MITCHELL, DM ;
NEUSTADT, DH ;
PINALS, RS ;
SCHALLER, JG ;
SHARP, JT ;
WILDER, RL ;
HUNDER, GG .
ARTHRITIS AND RHEUMATISM, 1988, 31 (03) :315-324
[6]   Periodontitis and rheumatoid arthritis: A review [J].
Bartold, PM ;
Marshall, RI ;
Haynes, DR .
JOURNAL OF PERIODONTOLOGY, 2005, 76 (11) :2066-2074
[7]  
Bascones A, 2005, QUINTESSENCE INT, V36, P299
[8]   Socioeconomic status and the risk of developing rheumatoid arthritis: results from the Swedish EIRA study [J].
Bengtsson, C ;
Nordmark, B ;
Klareskog, L ;
Lundberg, I ;
Alfredsson, L .
ANNALS OF THE RHEUMATIC DISEASES, 2005, 64 (11) :1588-1594
[9]   Evaluation of t-PA, PAI-2, IL-1β and PGE2 in gingival crevicular fluid of rheumatoid arthritis patients with periodontal disease [J].
Biyikoglu, Basak ;
Buduneli, Nurcan ;
Kardesler, Levent ;
Aksu, Kenan ;
Oeder, Gonca ;
Kuetuekcueler, Necil .
JOURNAL OF CLINICAL PERIODONTOLOGY, 2006, 33 (09) :605-611
[10]   Validation of self-reported periodontal disease: A systematic review [J].
Blicher, B ;
Joshipura, K ;
Eke, P .
JOURNAL OF DENTAL RESEARCH, 2005, 84 (10) :881-890