Enantio- and diastereoselective synthesis of N-[(1R,2R,3R,4R)-2,3-diacetoxy-4-(acetoxymethyl)cyclopentyl]acetamide, a synthetic key intermediate of (+)-cyclaradine

被引：0

作者：

Norimine, Y ^{[1
]}

Hayashi, M ^{[1
]}

Tanaka, M ^{[1
]}

Suemune, H ^{[1
]}

机构：

[1] Kyushu Univ, Fac Pharmaceut Sci, Fukuoka 8128582, Japan

来源：

CHEMICAL & PHARMACEUTICAL BULLETIN | 1998年 / 46卷 / 05期

关键词：

(+)-cyclaradine; enantio- and diastereoselective synthesis; enantiomerically pure form;

D O I：

暂无

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Enantio- and diastereoselective synthesis of N-[(1R,2R,3R,4R)-2,3-diacetoxy-4-(acetoxymethyl)cyclopentyl]-acetamide 1, a synthetic key intermediate of (+)-cyclaradine, has been achieved by using enzyme-catalyzed asymmetric hydrolysis and subsequent modification of a functional group.

引用

页码：842 / 845

页数：4

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