Correlation of IL-10 and IL-2 single gene polymorphisms with the susceptibility to pigeon breeder's lung in Chinese Uygur population

Objective: To investigate the correlation of interleukin (IL)-10 and IL-2 gene single nucleotide polymorphisms (SNP) with the susceptibility to pigeon breeder's lung (PBL) in Chinese Uygur population. Methods: A total of 92 Uygur from Xinjiang, China were enrolled in the study. Among them, there were 32 patients with PBL, 30 negative controls with history of exposure to pigeons and 30 normal controls without pigeons contact. SNP genotyping for 16 SNPs of IL-10 and 4 SNPs of IL-2 were performed. Results: Genotypes and alleles of 16 IL-10 SNPs were not significantly different between the three groups. GT genotype of IL-2 rs2069762 had significant association with the susceptibility to PBL. However, alleles of IL-2 SNPs were not significantly different between the three groups (P = 0.719). Conclusion: Chinese Uygur pigeon breeders with GT genotype of IL-2 rs2069762 had more risk to have PBL compared with those with GG and TT genotype (OR 16.545, 95% CI 1.814-150.930, P = 0.002; OR 5.673, 95% CI 1.611-19.981, P = 0.005).