The relationship between ventilatory function and cognitive and behavioral impairment in ALS

被引：4

作者：

Shah, Jaimin S. ^{[1
]}

Pedraza, Otto ^{[2
]}

Festic, Emir ^{[3
]}

Oskarsson, Bjorn ^{[1
]}

机构：

[1] Mayo Clin, Neurol, Jacksonville, FL 32224 USA

[2] Mayo Clin, Psychiat & Psychol, Jacksonville, FL 32224 USA

[3] Mayo Clin, Allergy & Pulm Med, Jacksonville, FL 32224 USA

来源：

AMYOTROPHIC LATERAL SCLEROSIS AND FRONTOTEMPORAL DEGENERATION | 2021年 / 22卷

关键词：

ALS; cognition; behavior; ventilation; AMYOTROPHIC-LATERAL-SCLEROSIS; NONINVASIVE VENTILATION; DYSFUNCTION; EXCITOTOXICITY; COMPLICATIONS; UPDATE;

D O I：

10.1080/21678421.2021.1924206

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Objective: To study the association between ventilatory function and cognitive and behavioral impairment in ALS patients accounting for the effects of pertinent covariates. Methods: Four hundred and eighty-one patients were identified from the Mayo Clinic Florida ALS registry who had concurrent forced vital capacity (FVC) and cognitive and behavioral testing using the ALS Cognitive Behavioral Screen (ALS-CBS). Multiple linear regression analysis was used to study the effects of FVC and relevant covariates on the ALS-CBS cognition score, subscores, and caregiver behavioral inventory. Results: FVC was positively correlated to the cognitive and behavioral subscores on the ALS-CBS (p < 0.001), and the correlation was independent of the effects of site of ALS onset, age, and years of education. Conclusion: Cognitive and behavioral function may be adversely affected by ventilatory impairment in ALS. The presence of cognitive and behavioral impairment warrants a detailed assessment of ventilatory function.

引用

页码：62 / 67

页数：6

共 35 条

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