Two new triterpene lactones from the stems of Kadsura polysperma

被引:14
作者
Jia, Zhengwei [1 ]
Lu, Yan [1 ]
Liao, Zhixin [1 ]
Chen, Daofeng [1 ]
机构
[1] Fudan Univ, Dept Pharmacognosy, Sch Pharm, Shanghai 200032, Peoples R China
关键词
D O I
10.1002/hlca.200790124
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Two new triterpene lactones, polysperlactones A (2) and B (3), were isolated from the stems of Kadsura polysperma, together with the known compounds heteroclitalactone D (1) and schisanlactone E (4). Their structures were elucidated by spectroscopic methods, including 2D-NMR and HR-MS techniques. The configuration of 1 was confirmed by X-ray analysis. Compounds 2 and 3 are members of a rare class of 3,4-secolanostane metabolites with ring-expanded or cyclized structures, respectively.
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收藏
页码:1236 / 1243
页数:8
相关论文
共 12 条
[1]   DIBENZOCYCLO-OCTADIENE LIGNANS FROM KADSURA-HETEROCLITA [J].
CHEN, DF ;
XU, GJ ;
YANG, XW ;
HATTORI, M ;
TEZUKA, Y ;
KIKUCHI, T ;
NAMBA, T .
PHYTOCHEMISTRY, 1992, 31 (02) :629-632
[2]   Anti-AIDS agents .26. Structure-activity correlations of gomisin-G-related anti-HIV lignans from Kadsura interior and of related synthetic analogues [J].
Chen, DF ;
Zhang, SX ;
Xie, L ;
Xie, JX ;
Chen, K ;
Kashiwada, Y ;
Zhou, BN ;
Wang, P ;
Cosentino, LM ;
Lee, KH .
BIOORGANIC & MEDICINAL CHEMISTRY, 1997, 5 (08) :1715-1723
[3]   Interiotherins C and D, two new lignans from Kadsura interior and antitumor-promoting effects of related neolignans on Epstein-Barr virus activation [J].
Chen, DF ;
Zhang, SX ;
Kozuka, M ;
Sun, QZ ;
Feng, J ;
Wang, Q ;
Mukainaka, T ;
Nobukuni, Y ;
Tokuda, H ;
Nishino, H ;
Wang, HK ;
Morris-Natschke, SL ;
Lee, KH .
JOURNAL OF NATURAL PRODUCTS, 2002, 65 (09) :1242-1245
[4]   Two new lignans, interiotherins A and B, as anti-HIV principles from Kadsura interior [J].
Chen, DF ;
Zhang, SX ;
Chen, K ;
Zhou, BN ;
Wang, P ;
Cosentino, LM ;
Lee, KH .
JOURNAL OF NATURAL PRODUCTS, 1996, 59 (11) :1066-1068
[5]   Novel anti-HIV lancilactone C and related triterpenes from Kadsura lancilimba [J].
Chen, DF ;
Zhang, SX ;
Wang, HK ;
Zhang, SY ;
Sun, QZ ;
Cosentino, LM ;
Lee, KH .
JOURNAL OF NATURAL PRODUCTS, 1999, 62 (01) :94-97
[6]  
CHEN DF, 1996, J SHANGHAI MED U S, V23, P52
[7]  
Chen YG, 2001, CHINESE J CHEM, V19, P304
[8]   A TRITERPENOID FROM KATSURA-HETEROCLITA [J].
CHEN, YP ;
LIN, ZW ;
ZHANG, HJ ;
SUN, HD .
PHYTOCHEMISTRY, 1990, 29 (10) :3358-3359
[9]  
LIU JS, 1991, ACTA CHIM SINICA, V49, P502
[10]  
LIU JS, 1984, ACTA CHIM SINICA, V42, P464