Benzoquinones from Ardisia japonica with inhibitory activity towards human protein tyrosine phosphatase 1B (PTP1B)

被引：11
|
作者：
Li, Yan-Fang
Li, Jia
Shen, Qiang
Hu, Li-Hong [1 ]
机构：
[1] Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai Res Ctr Modernizat Tradit Chinese Med, Shanghai 201203, Peoples R China
[2] Sichuan Univ, Dept Pharmaceut & Bioengn, Chengdu 610065, Peoples R China
[3] E China Univ Sci & Technol, Sch Pharm, Shanghai 200237, Peoples R China
来源：
CHEMISTRY & BIODIVERSITY | 2007年 / 4卷 / 05期
关键词：
D O I：
10.1002/cbdv.200790086
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
From the whole plant of Ardisia japonica, four [1,4]benzoquinones were isolated by means of bioassay-directed fractionation of the EtOH extract. Apart from the two known compounds maesanin (1) and its congener 2, two new benzoquinones, i.e., 5-ethoxy-2-hydroxy-3-[(10Z)-pentadec-10-en-1-yl][1,4]benzoquinone (3) and 5-ethoxy-2-hydroxy-3-[(8Z)-tridec-8-en-1-yl] [ 1,4] benzoquinone (4), were identified. All compounds showed significant in vitro bioactivities against the PTP1B enzyme, with IC50 values in the range of ca. 3 - 19 mu m.
引用
收藏
页码：961 / 965
页数：5
相关论文
共 50 条
  • [1] Inhibitors of protein tyrosine phosphatase 1B (PTP1B)
    Taylor, SD
    CURRENT TOPICS IN MEDICINAL CHEMISTRY, 2003, 3 (07) : 759 - 782
  • [2] Protein Tyrosine Phosphatase 1B (PTP1B) and Obesity
    Cho, Hyeongjin
    OBESITY, 2013, 91 : 405 - 424
  • [3] Oleanane triterpenes as protein tyrosine phosphatase 1B (PTP1B) inhibitors from Camellia japonica
    Uddin, Mohammad Nasir
    Sharma, Govinda
    Yang, Jun-Li
    Choi, Hong Seok
    Lim, Seong-Il
    Kang, Keon Wook
    Oh, Won Keun
    PHYTOCHEMISTRY, 2014, 103 : 99 - 106
  • [4] Protein tyrosine phosphatase 1B (PTP1B) inhibitory activity and glucosidase inhibitory activity of compounds isolated from Agrimonia pilosa
    Na, Braham
    Phi-Hung Nguyen
    Zhao, Bing-Tian
    Quoc-Hung Vo
    Min, Byung Sun
    Woo, Mi Hee
    PHARMACEUTICAL BIOLOGY, 2016, 54 (03) : 474 - 480
  • [5] New Prenylated Flavanones from Erythrina abyssinica with Protein Tyrosine Phosphatase 1B (PTP1B) Inhibitory Activity
    Cui, Long
    Lee, Hyun Sun
    Ndinteh, Derek Tantoh
    Mbafor, Joseph Tanyi
    Kim, Young Ho
    Le, Thi Van Thu
    Nguyen, Phi Hung
    Oh, Won Keun
    PLANTA MEDICA, 2010, 76 (07) : 713 - 718
  • [6] New 5-deoxyflavonoids and their inhibitory effects on protein tyrosine phosphatase 1B (PTP1B) activity
    Phi Hung Nguyen
    Dao, Trong Tuan
    Kim, Jayeon
    Phong, Do Tuan
    Ndinteh, Derek Tantoh
    Mbafor, Joseph Tanyi
    Oh, Won Keun
    BIOORGANIC & MEDICINAL CHEMISTRY, 2011, 19 (11) : 3378 - 3383
  • [7] PTP1B inhibitors from Ardisia japonica
    Li, YF
    Hu, LH
    Lou, FC
    Li, J
    Shen, Q
    JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH, 2005, 7 (01) : 13 - 18
  • [8] Insulin-Mimetic Selaginellins from Selaginella tamariscina with Protein Tyrosine Phosphatase 1B (PTP1B) Inhibitory Activity
    Phi-Hung Nguyen
    Zhao, Bing-Tian
    Ali, Md Yousof
    Choi, Jae-Sue
    Rhyu, Dong-Young
    Min, Byung-Sun
    Woo, Mi-Hee
    JOURNAL OF NATURAL PRODUCTS, 2015, 78 (01): : 34 - 42
  • [9] Four new neolignans isolated from Eleutherococcus senticosus and their protein tyrosine phosphatase 1B inhibitory activity (PTP1B)
    Zhang, Le
    Li, Ban-Ban
    Li, Hao-Ze
    Meng, Xiao
    Lin, Xin
    Jiang, Yi-Yu
    Ahn, Jong-Seog
    Cui, Long
    FITOTERAPIA, 2017, 121 : 58 - 63
  • [10] Human Protein Tyrosine Phosphatase 1B (PTP1B): From Structure to Clinical Inhibitor Perspectives
    Liu, Rongxing
    Mathieu, Cecile
    Berthelet, Jeremy
    Zhang, Wenchao
    Dupret, Jean-Marie
    Lima, Fernando Rodrigues
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2022, 23 (13)
12345