Peroxisome proliferator-activated receptor ligands in atherosclerosis

被引：10
|
作者：
Viles-Gonzalez, JF [1 ]
Choi, BG [1 ]
Fuster, V [1 ]
Badimon, JJ [1 ]
机构：
[1] CUNY Mt Sinai Sch Med, Zena & Michael A Wiener Cardiovasc Inst, Cardiovasc Biol Res Lab, New York, NY 10029 USA
来源：
EXPERT OPINION ON INVESTIGATIONAL DRUGS | 2004年 / 13卷 / 11期
关键词：
atherosclerosis; coronary artery disease; fibrate; PPAR; thiazolidinedione;
D O I：
10.1517/13543784.13.11.1393
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
in this review, the effect of peroxisome proliferator-activated receptor (PPAR) ligands on atherosclerosis is examined. The PPAR-gamma agonist thiazolidinediones are currently indicated for the management of Type 2 diabetes mellitus, and the PPAR-alpha agonist fibrates are used in dyslipidaemia. Here their mechanism of action and the pre-clinical and clinical evidence for the use of these medications for the prevention and treatment of atherosclerotic disease is explored. In addition, the role of PPAR-delta and the possibilities for the role of dual-binding agonists; are examined.
引用
收藏
页码：1393 / 1403
页数：11
相关论文
共 50 条
  • [1] Peroxisome proliferator-activated receptor γ ligands and atherosclerosis:: ending the heartache
    Rosen, ED
    Spiegelman, BM
    JOURNAL OF CLINICAL INVESTIGATION, 2000, 106 (05): : 629 - 631
  • [2] Peroxisome proliferator-activated receptor γ and atherosclerosis
    Marx, N
    CURRENT HYPERTENSION REPORTS, 2002, 4 (01) : 71 - 77
  • [3] Peroxisome proliferator-activated receptor γ and atherosclerosis
    Nikolaus Marx
    Current Hypertension Reports, 2002, 4 : 71 - 77
  • [4] Role of peroxisome proliferator-activated receptor α in atherosclerosis
    Cao, Heng
    Wen, Gao
    Li, Hongli
    MOLECULAR MEDICINE REPORTS, 2014, 9 (05) : 1755 - 1760
  • [5] The expression and role of peroxisome proliferator-activated receptor α in atherosclerosis
    Gao, Wen
    Xu, Wei
    Li, Hongli
    MOLECULAR MEDICINE REPORTS, 2013, 7 (03) : 862 - 868
  • [6] Peroxisome Proliferator-Activated Receptor a in Lipid Metabolism and Atherosclerosis
    Yu, Xiao-Hua
    Zheng, Xi-Long
    Tang, Chao-Ke
    ADVANCES IN CLINICAL CHEMISTRY, VOL 71, 2015, 71 : 171 - 203
  • [7] Peroxisome proliferator-activated receptor agonists, hyperlipidaemia, and atherosclerosis
    Vosper, H
    Khoudoli, GA
    Graham, TL
    Palmer, CNA
    PHARMACOLOGY & THERAPEUTICS, 2002, 95 (01) : 47 - 62
  • [8] Ligands for the Nuclear Peroxisome Proliferator-Activated Receptor Gamma
    Sauer, Sascha
    TRENDS IN PHARMACOLOGICAL SCIENCES, 2015, 36 (10) : 688 - 704
  • [9] Peroxisome Proliferator-Activated Receptors and Atherosclerosis
    Soskic, Sanja S.
    Dobutovic, Branislava D.
    Sudar, Emina M.
    Obradovic, Milan M.
    Nikolic, Dragana M.
    Zaric, Bozidarka L.
    Stojanovic, Srdan D.
    Stokic, Edita J.
    Mikhailidis, Dimitri P.
    Isenovic, Esma R.
    ANGIOLOGY, 2011, 62 (07) : 523 - 534
  • [10] Lipid metabolism:: peroxisome proliferator-activated receptor-α and atherosclerosis
    van Greevenbroek, MMJ
    van der Kallen, CJH
    CURRENT OPINION IN LIPIDOLOGY, 2002, 13 (02) : 223 - 225
12345