Genetic correlates of social stratification in Great Britain

被引：154

作者：

Abdellaoui, Abdel ^{[1
]}

Hugh-Jones, David ^{[2
]}

Yengo, Loic ^{[3
]}

Kemper, Kathryn E. ^{[3
]}

Nivard, Michel G. ^{[4
]}

Veul, Laura ^{[1
]}

Holtz, Yan ^{[3
]}

Zietsch, Brendan P. ^{[5
]}

Frayling, Timothy M. ^{[6
]}

Wray, Naomi R. ^{[3
,7
]}

Yang, Jian ^{[3
,7
]}

Verweij, Karin J. H. ^{[1
]}

Visscher, Peter M. ^{[3
,7
]}

机构：

[1] Univ Amsterdam, Dept Psychiat, Amsterdam UMC, Amsterdam, Netherlands

[2] Univ East Anglia, Dept Econ, Norwich, Norfolk, England

[3] Univ Queensland, Inst Mol Biosci, Brisbane, Qld, Australia

[4] Vrije Univ Amsterdam, Dept Biol Psychol, Amsterdam, Netherlands

[5] Univ Queensland, Sch Psychol, Brisbane, Qld, Australia

[6] Univ Exeter, Med Sch, Genet Complex Traits, Exeter, Devon, England

[7] Univ Queensland, Queensland Brain Inst, Brisbane, Qld, Australia

来源：

NATURE HUMAN BEHAVIOUR | 2019年 / 3卷 / 12期

基金：

美国国家卫生研究院; 英国医学研究理事会; 澳大利亚研究理事会;

关键词：

GENOME-WIDE ASSOCIATION; COMPLEX TRAITS; MIGRATION; DEPRIVATION; SELECTION; HEALTH; INEQUALITIES; GEOGRAPHY; VARIANTS; PITFALLS;

D O I：

10.1038/s41562-019-0757-5

中图分类号：

B84 [心理学];

学科分类号：

04 ; 0402 ;

摘要：

Human DNA polymorphisms vary across geographic regions, with the most commonly observed variation reflecting distant ancestry differences. Here we investigate the geographic clustering of common genetic variants that influence complex traits in a sample of similar to 450,000 individuals from Great Britain. Of 33 traits analysed, 21 showed significant geographic clustering at the genetic level after controlling for ancestry, probably reflecting migration driven by socioeconomic status (SES). Alleles associated with educational attainment (EA) showed the most clustering, with EA-decreasing alleles clustering in lower SES areas such as coal mining areas. Individuals who leave coal mining areas carry more EA-increasing alleles on average than those in the rest of Great Britain. The level of geographic clustering is correlated with genetic associations between complex traits and regional measures of SES, health and cultural outcomes. Our results are consistent with the hypothesis that social stratification leaves visible marks in geographic arrangements of common allele frequencies and gene-environment correlations.

引用

页码：1332 / +

页数：21

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