von Willebrand disease;
VWD;
von Willebrand factor;
VWF;
history of VWD;
inherited bleeding disorder;
DISEASE;
D O I:
10.1016/j.thromres.2007.03.010
中图分类号:
R5 [内科学];
学科分类号:
1002 ;
100201 ;
摘要:
In 1926, Erik von Willebrand, a Finnish physician, published the first manuscript describing a haemorrhagic disorder in people who were living on the Aland islands off the coast of Finland. This disorder is now known by the name of its discoverer. Since this early observation, von Willebrand disease has been extensively studied. Today, we know the structure and function of the von Willebrand factor and much of its molecular biology. With the availability of safe and effective products, the treatment of von Willebrand disease is continually improving. (c) 2007 Elsevier Ltd. All rights reserved.
机构:
Washington Univ, Sch Med, Dept Pediat, Div Hematol Oncol, 660 S Euclid Ave,Campus Box 8208, St Louis, MO 63110 USAWashington Univ, Sch Med, Dept Pediat, Div Hematol Oncol, 660 S Euclid Ave,Campus Box 8208, St Louis, MO 63110 USA
Sadler, Brooke
Castaman, Giancarlo
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机构:
Careggi Univ Hosp, Dept Oncol, Ctr Bleeding Disorders & Coagulat, Florence, ItalyWashington Univ, Sch Med, Dept Pediat, Div Hematol Oncol, 660 S Euclid Ave,Campus Box 8208, St Louis, MO 63110 USA
Castaman, Giancarlo
O'Donnell, James S.
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机构:
Royal Coll Surgeons Ireland, Sch Pharm & Biomol Sci, Irish Ctr Vasc Biol, Dublin 2, Ireland
St James Hosp, Natl Coagulat Ctr, Dublin, IrelandWashington Univ, Sch Med, Dept Pediat, Div Hematol Oncol, 660 S Euclid Ave,Campus Box 8208, St Louis, MO 63110 USA