Anti-calcitonin gene-related peptide antibody attenuates orofacial mechanical and heat hypersensitivities induced by infraorbital nerve injury

被引：4
作者：
Maegawa, Hiroharu [1 ]
Yoshikawa, Chiaki [1 ]
Usami, Nayuka [1 ]
Hanamoto, Hiroshi [1 ]
Kudo, Chiho [1 ]
Niwa, Hitoshi [1 ]
机构：
[1] Osaka Univ, Grad Sch Dent, Dept Dent Anesthesiol, Suita, Osaka 5650871, Japan
来源：
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2021年 / 569卷
关键词：
Calcitonin gene-related peptide; Chronic constriction injury; Orofacial sensory hypersensitivity; Trigeminal spinal subnucleus caudalis; Phosphorylated extracellular signal-regulated kinase; RHESUS-MONKEY; RECEPTOR; CGRP; PAIN; NEURONS; KETANSERIN; ALLODYNIA; MODEL; RATS;
D O I：
10.1016/j.bbrc.2021.07.001
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Currently, limited information regarding the role of calcitonin gene-related peptide (CGRP) in neuropathic pain is available. Intracerebroventricular administrations of an anti-CGRP antibody were performed in rats with infraorbital nerve ligation. Anti-CGRP antibody administration attenuated mechanical and heat hypersensitivities induced by nerve ligation and decreased the phosphorylated extracellular signal-regulated kinase expression levels in the trigeminal spinal subnucleus caudalis (Vc) following mechanical or heat stimulation. An increased CGRP immunoreactivity in the Vc appeared after nerve ligation. A decreased CGRP immunoreactivity resulted from anti-CGRP antibody administration. Our findings suggest that anti-CGRP antibody administration attenuates the symptoms of trigeminal neuropathic pain by acting on CGRP in the Vc. (c) 2021 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
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收藏
页码：147 / 153
页数：7
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