The aging immune system in Alzheimer's and Parkinson's diseases

被引：26
作者：
Heavener, Kelsey S. [1 ]
Bradshaw, Elizabeth M. [1 ]
机构：
[1] Columbia Univ, Irving Med Ctr, Dept Neurol, New York, NY 10032 USA
来源：
SEMINARS IN IMMUNOPATHOLOGY | 2022年 / 44卷 / 05期
关键词：
Alzheimer's disease; Parkinson's disease; Microglia; T cells; Immunosenescence; GENOME-WIDE ASSOCIATION; ALPHA-SYNUCLEIN; COMMON VARIANTS; T-CELLS; DYSTROPHIC MICROGLIA; CEREBROSPINAL-FLUID; REACTIVE MICROGLIA; APOLIPOPROTEIN-E; HLA-DR; BRAIN;
D O I：
10.1007/s00281-022-00944-6
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The neurodegenerative diseases Alzheimer's disease (AD) and Parkinson's disease (PD) both have a myriad of risk factors including genetics, environmental exposures, and lifestyle. However, aging is the strongest risk factor for both diseases. Aging also profoundly influences the immune system, with immunosenescence perhaps the most prominent outcome. Through genetics, mouse models, and pathology, there is a growing appreciation of the role the immune system plays in neurodegenerative diseases. In this review, we explore the intersection of aging and the immune system in AD and PD.
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收藏
页码：649 / 657
页数：9
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