A highly selective ratiometric fluorescent probe for 1,4-dithiothreitol (DTT) detection

被引：38
|
作者：
Zhu, Baocun [1 ]
Zhang, Xiaoling [1 ]
Jia, Hongying [2 ]
Li, Yamin [1 ]
Liu, Haipeng [3 ,4 ,5 ]
Tan, Weihong [3 ,4 ,5 ]
机构：
[1] Beijing Inst Technol, Sch Sci, Dept Chem, Beijing 100081, Peoples R China
[2] Chinese Acad Sci, Inst Chem, Beijing 100190, Peoples R China
[3] Univ Florida, Dept Chem, Ctr Res Bio Nano Interface, Gainesville, FL 32611 USA
[4] Univ Florida, Shands Canc Ctr, Genet Inst, Dept Physiol & Funct Genom, Gainesville, FL 32611 USA
[5] Univ Florida, McKnight Brain Inst, Gainesville, FL 32611 USA
来源：
ORGANIC & BIOMOLECULAR CHEMISTRY | 2010年 / 8卷 / 07期
关键词：
CATALYZED OXIDATION; ELECTRON-TRANSFER; ESCHERICHIA-COLI; DITHIOTHREITOL; HOMOCYSTEINE; CHEMOSENSOR; THIOLS; SENSOR; REAGENT; DNA;
D O I：
10.1039/b923754b
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A highly selective ratiometric fluorescent probe, which contains an aminonaphthalimide fluorophore and a self-immolative spacer for 1,4-dithiothreitol (DTT) detection was designed and synthesized. The probe displays a 66 nm red-shift of fluorescence emission and the color changes from colorless to jade-green upon reaction with DTT. These properties are mechanistically ascribed to the strong reducing capability of DTT.
引用
收藏
页码：1650 / 1654
页数：5
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