SYNTHESIS AND CHARACTERIZATION OF SOME NEW 5-BROMO-2-HYDROXY-BENZAMIDE DERIVATIVES

Compounds with 2-hydroxy-benzamide structure are well known for their biological activity. Thus, synthesizing the derivatives of this moiety without its side effects has been a constant challenge for the medicinal chemistry. Consequently, we considered worthwhile to synthesize some 5-bromo-salicylamide derivatives which might possess enhanced biological activity. Starting from 5-bromo-2-hydroxybenzamide and methyl/ethyl alpha-halogenated acid esters were obtained methyl/ethyl esters, which in reaction with hydrazine provide hydrazides. In the next step, hydrazides were condensated with substituted benzaldehydes, obtaining hydrazones. In order to assess the structural identity of the synthesized compounds, modern physico-chemical methods (FTIR, C-13-NMR, MS) were employed. For all analyzed compounds, the obtained data proved their identity and provide their elemental composition.